Häyry P, von Willebrand E
Proc Eur Dial Transplant Assoc. 1978;15:335-42.
The rate of spontaneous proliferative activity of blood leucocytes, the presence of donor-directed cytotoxic cells in the circulation of transplant recipients and the fine-needle aspiration cytology of the transplant have been evaluated for the monitoring of acute rejection episodes in 8 recipients of cadaver kidney transplants. We could not find any correlation between the rate of proliferative activity of the appearance of cytotoxic cells in the recipients' circulation on the one hand, and the onset of rejection on the other hand. A detectable blast response, consisting of lymphoblasts and plasmablasts could, however, be seen inside the kidney parenchyma during the early stages of rejection. We propose that the blast response could be used for the monitoring of rejection episodes in kidney transplant recipients.
对8例尸体肾移植受者进行了评估，以监测急性排斥反应发作，评估指标包括血液白细胞的自发增殖活性、移植受者循环中供体定向细胞毒性细胞的存在情况以及移植组织的细针穿刺细胞学检查。一方面，我们未发现受者循环中细胞毒性细胞出现的增殖活性速率与另一方面的排斥反应发作之间存在任何相关性。然而，在排斥反应早期阶段，可在肾实质内观察到由成淋巴细胞和浆母细胞组成的可检测到的母细胞反应。我们建议，母细胞反应可用于监测肾移植受者的排斥反应发作。
