Jiang Nan, Bao Wen-Wen, Gui Zhao-Huan, Chen Yi-Can, Zhao Yu, Huang Shan, Zhang Yu-Shan, Liang Jing-Hong, Pu Xue-Ya, Huang Shao-Yi, Dong Guang-Hui, Chen Ya-Jun
Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
Environ Res. 2023 May 15;225:115611. doi: 10.1016/j.envres.2023.115611. Epub 2023 Mar 4.
Air pollution exposures are increasingly suspected to influence the development of childhood adiposity, especially focusing on outdoor exposure, but few studies investigated indoor exposure and childhood obesity.
We aimed to examine the association between exposure to multiple indoor air pollutants and childhood obesity in Chinese schoolchildren.
In 2019, we recruited 6499 children aged 6-12 years from five Chinese elementary schools in Guangzhou, China. We measured age-sex-specific body mass index z score (z-BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) on standard procedures. Four different indoor air pollution (IAP) exposures, including cooking oil fumes (COFs), home decoration, secondhand smoke (SHS), and incense burning, were collected by questionnaire and then converted into an IAP exposure index with four categories. Association between indoor air pollutants and childhood overweight/obesity as well as four obese anthropometric indices were assessed by logistic regression models and multivariable linear regression models, respectively.
Children exposed to ≥3 types of indoor air pollutants had higher z-BMI (coefficient [β]:0.142, 95% confidence interval [CI]:0.011-0.274) and higher risk of overweight/obesity (odd ratio [OR]:1.27, 95%CI:1.01-1.60). And a dose-response relationship was discovered between the IAP exposure index and z-BMI as well as overweight/obesity (p<0.05). We also found that exposure to SHS and COFs was positively associated with z-BMI and overweight/obesity (p < 0.05). Moreover, there was a significant interaction between SHS exposure and COFs on the higher risk of overweight/obesity among schoolchildren. Boys appear more susceptible to multiple indoor air pollutants than girls.
Indoor air pollution exposures were positively associated with higher obese anthropometric indices and increased odds of overweight/obesity in Chinese schoolchildren. More well-designed cohort studies are needed to verify our results.
空气污染暴露越来越多地被怀疑会影响儿童肥胖的发展，尤其是关注室外暴露，但很少有研究调查室内暴露与儿童肥胖的关系。
我们旨在研究中国学龄儿童接触多种室内空气污染物与儿童肥胖之间的关联。
2019年，我们从中国广州的五所小学招募了6499名6至12岁的儿童。我们按照标准程序测量了按年龄和性别划分的体重指数z评分（z-BMI）、腰围（WC）、腰臀比（WHR）和腰高比（WHtR）。通过问卷调查收集了四种不同的室内空气污染（IAP）暴露情况，包括烹饪油烟（COF）、家庭装修、二手烟（SHS）和焚香，然后将其转换为具有四个类别的IAP暴露指数。分别通过逻辑回归模型和多变量线性回归模型评估室内空气污染物与儿童超重/肥胖以及四个肥胖人体测量指标之间的关联。
接触≥3种室内空气污染物的儿童z-BMI更高（系数[β]：0.142，95%置信区间[CI]：0.011 - 0.274），超重/肥胖风险更高（比值比[OR]：1.27，95%CI：1.01 - 1.60）。并且发现IAP暴露指数与z-BMI以及超重/肥胖之间存在剂量反应关系（p<0.05）。我们还发现，接触SHS和COF与z-BMI和超重/肥胖呈正相关（p < 0.05）。此外，SHS暴露和COF之间在学龄儿童超重/肥胖的较高风险上存在显著交互作用。男孩似乎比女孩更容易受到多种室内空气污染物的影响。
在中国学龄儿童中，室内空气污染暴露与较高的肥胖人体测量指标以及超重/肥胖几率增加呈正相关。需要更多设计良好的队列研究来验证我们的结果。
