Remuzzi G, Bertani T, Livio M, Cavenaghi A E, Mysliwiec M, Marchesi D, Donati M C, de Gaetano G, Mecca G
Proc Eur Dial Transplant Assoc. 1978;15:449-55.
To determine the possible role of vascular factors in the bleeding tendency of uraemic patients, three major factors of the haemostatic system normally present in vascular tissues were studied. Factor VIII-related protein (F VIII) was detected on the vascular intima of 13 patients and 10 normal subjects. Comparable values of plasminogen activator (PA) were found in tissue slices from 7 patients and 7 controls. In contrast, prostacyclin like (PGI2) activity, measured as platelet aggregation inhibitory potency, was significantly higher in specimens from 15 patients with either acute or chronic uraemia than in 10 controls. The latter abnormality, leading to impaired platelet-vessel wall interaction, might contribute to the disturbed haemostasis of uraemic patients.
为了确定血管因素在尿毒症患者出血倾向中可能起到的作用，对通常存在于血管组织中的止血系统的三个主要因素进行了研究。在13例患者和10名正常受试者的血管内膜上检测到了VIII因子相关蛋白（F VIII）。在7例患者和7名对照的组织切片中发现了类似的纤溶酶原激活剂（PA）值。相比之下，以血小板聚集抑制效力衡量的前列环素样（PGI2）活性，在15例急性或慢性尿毒症患者的标本中显著高于10名对照。后一种异常导致血小板与血管壁相互作用受损，可能是尿毒症患者止血紊乱的原因。
