Schmitt E, Seyfarth M, Templin R, Schneider P, Klinkmann H
Proc Eur Dial Transplant Assoc. 1978;15:466-72.
Urinary fibrin degradation products (FDP) were determined by Merskey's passive haemagglutination test in 115 patients with biopsy proven chronic proliferative glomerulonephritis (GN), 94 with urinary tract infection (UTI), and 23 transplanted patients. The active GN values (12.3 microgram/ml) are significantly higher than those for latent GN (0.3 microgram/ml). Those for acute UTI (9.2 microgram/ml) are significantly higher than for chronic UTI (1.3 microgram/ml). In contrast to the reports published by others, the numerous 'false positive' and 'false negative' values make diagnosis of the activity unreliable. Some prognostic value can be expected in GN with the nephrotic syndrome (NS): patients with steroid-sensitive NS excrete no FDP and patients with steroid-resistant NS excrete larger quantities of FDP. We have confirmed that a rise in FDP level following kidney transplantation is indicative of an acute rejection crisis. However, since 10 of 27 rejections were FDP negative, the absence of FDP in the urine does not preclude rejection, so that the diagnostic value is restricted.
采用默斯基被动血凝试验测定了115例经活检证实为慢性增殖性肾小球肾炎（GN）患者、94例尿路感染（UTI）患者和23例移植患者的尿纤维蛋白降解产物（FDP）。活动性GN患者的值（12.3微克/毫升）显著高于潜伏性GN患者（0.3微克/毫升）。急性UTI患者的值（9.2微克/毫升）显著高于慢性UTI患者（1.3微克/毫升）。与其他人发表的报告相反，大量的“假阳性”和“假阴性”值使得对活动性的诊断不可靠。对于肾病综合征（NS）的GN患者，可能具有一定的预后价值：激素敏感型NS患者不排出FDP，而激素抵抗型NS患者排出大量FDP。我们已经证实，肾移植后FDP水平升高表明发生了急性排斥反应危机。然而，由于27次排斥反应中有10次FDP为阴性，尿中无FDP并不能排除排斥反应，因此其诊断价值有限。
