Cavallini A, Messa C, Mangini V, Argese V, Misciagna G, Giorgio I
Laboratorio di Fisipatologia Digestiva, Istituto di Ricovero e Cura a Carattere Scientifico Castellana G, (Bari), Italy.
Am J Gastroenterol. 1987 Dec;82(12):1279-82.
To investigate the relationship between blood and bile lipids, serum cholesterol, high density lipoprotein cholesterol, and triglycerides were correlated with cholesterol saturation index of bile in 21 women-10 with radiolucent gallstones and 11 without stones. All of the women had regular menstrual cycles, were normolipidemic, and on a hospital diet. On the same morning, blood and the darkest duodenal bile were taken after cholecystokinin (CCK) stimulation. Standard laboratory procedures were used to analyze serum and bile lipids. We found: 1) statistically significant (t test, p less than 0.05) but only slight hypercholesterolemia (+ 12%) in patients with gallstones; 2) a negative correlation of serum cholesterol with cholesterol saturation index of bile, both in the control group (r = -0.654, p less than 0.05) and in gallstone patients (r = -0.665, p less than 0.05); 3) a correlation of high density lipoprotein cholesterol with cholesterol saturation index only in normal women (r = -0.619, p less than 0.05); 4) conversely, a correlation of triglycerides with the same index in only gallstone patients (r = 0.641, p less than 0.05). With the stepwise multiple regression analysis (independent variables: diagnosis of gallstones, serum cholesterol, HDL cholesterol, triglycerides; dependent variable: biliary cholesterol saturation index), only gallstone diagnosis and serum cholesterol influenced significantly (F test, p less than 0.05) the biliary cholesterol saturation index. These findings suggest that young women with radiolucent gallstones are slightly hypercholesterolemic, that in women both with and without gallstones there is a negative correlation between serum cholesterol and biliary cholesterol saturation, but women with gallstones have a higher cholesterol saturation index of the bile than women without gallstones with the same level of cholesterol in the blood.
为研究血脂与胆汁脂质之间的关系，对21名女性（10名有透X线胆结石，11名无结石）的血清胆固醇、高密度脂蛋白胆固醇和甘油三酯与胆汁胆固醇饱和指数进行了相关性分析。所有女性月经周期规律，血脂正常，且均采用医院常规饮食。在同一天上午，经胆囊收缩素（CCK）刺激后采集血液和最暗的十二指肠胆汁。采用标准实验室方法分析血清和胆汁脂质。我们发现：1）胆结石患者存在具有统计学意义（t检验，p<0.05）但仅为轻度的高胆固醇血症（升高12%）；2）在对照组（r = -0.654，p<0.05）和胆结石患者组（r = -0.665，p<0.05）中，血清胆固醇与胆汁胆固醇饱和指数均呈负相关；3）仅在正常女性中，高密度脂蛋白胆固醇与胆固醇饱和指数呈相关（r = -0.619，p<0.05）；4）相反，仅在胆结石患者中，甘油三酯与同一指数呈相关（r = 0.641，p<0.05）。通过逐步多元回归分析（自变量：胆结石诊断、血清胆固醇、高密度脂蛋白胆固醇、甘油三酯；因变量：胆汁胆固醇饱和指数），仅胆结石诊断和血清胆固醇对胆汁胆固醇饱和指数有显著影响（F检验，p<0.05）。这些发现表明，有透X线胆结石的年轻女性存在轻度高胆固醇血症，在有胆结石和无胆结石的女性中，血清胆固醇与胆汁胆固醇饱和度均呈负相关，但在血液胆固醇水平相同的情况下，有胆结石的女性胆汁胆固醇饱和指数高于无胆结石的女性。
