Bergkvist L, Tabàr L, Bergström R, Adami H O
Department of Surgery, University Hospital, Uppsala, Sweden.
Am J Epidemiol. 1987 Dec;126(6):1075-81. doi: 10.1093/oxfordjournals.aje.a114746.
Epidemiologic data and information on the mammographic parenchymal pattern (classified according to Wolfe (Cancer 1976;37:2486-92)) were obtained from 38,757 (89%) of all women who were invited to undergo mammography in a population-based screening program in Kopparberg County, Sweden, starting in October 1977. The prevalence of the high-risk patterns (P2 and DY) was significantly higher in women aged 46-50 years than in any younger or older age group. A univariate analysis revealed that the odds ratio (OR) of having a high-risk pattern increased regularly with increasing age at first birth and was highest in nulliparous women. These associations remained evident in all age groups and were most pronounced in the oldest women. A history of breast biopsy increased the likelihood of having a high-risk pattern (OR = 1.57), whereas a similar weak overall association with prior cancer in the contralateral breast (OR = 1.40) and with familiar occurrence of breast cancer (OR = 1.20) was eliminated when other confounding factors were considered in a multivariate analysis. The authors conclude that characteristics of the reproductive lives of women have a significant and lifelong impact on their mammographic parenchymal patterns.
在瑞典厄勒布鲁县开展的一项基于人群的筛查项目中，自1977年10月起邀请所有女性接受乳房X线检查，从其中38757名（89%）女性中获取了流行病学数据以及乳房X线实质模式信息（根据沃尔夫分类法（《癌症》1976年；37:2486 - 92））。46 - 50岁女性中高危模式（P2和DY）的患病率显著高于任何较年轻或较年长的年龄组。单因素分析显示，初产年龄越大，出现高危模式的比值比（OR）有规律地增加，且在未生育女性中最高。这些关联在所有年龄组中均很明显，在年龄最大的女性中最为显著。乳房活检史增加了出现高危模式的可能性（OR = 1.57），而在多因素分析中考虑其他混杂因素时，与对侧乳房既往癌症（OR = 1.40）以及乳腺癌家族史（OR = 1.20）的类似微弱总体关联被消除。作者得出结论，女性生殖生活特征对其乳房X线实质模式有重大且终生的影响。
