Department of Life Sciences and Biotechnology, School of Pharmacy and Heath Products, University of Ferrara, Ferrara, Italy.
Department of Chemical, Pharmaceutical and Agricultural Sciences (DOCPAS), University of Ferrara, Ferrara, Italy.
Phytother Res. 2023 Jul;37(7):2915-2938. doi: 10.1002/ptr.7786. Epub 2023 Mar 6.
The understanding of the use of Magnolia officinalis L. (Magnoliaceae) as a possible dietary supplement for supporting the treatment of airway pathologies might be of clinical interest. Two commercially available bark extracts (M. officinalis extract [MOE]) were characterized by quantitation in honokiol and magnolol content by means of high-performance liquid chromatography with UV detection. MOE effects, as well as those of the reference compounds per se, on some targets connected to airway pathologies (antibacterial- and lung and trachea relaxing- activities) were investigated. Results showed that MOE possessed interesting antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pneumoniae. This was accompanied by a spasmolytic and antispasmodic activity, possibly owing to its ability to concurrently modulate different targets such as H -, β - and muscarinic receptors and l-type calcium channels involved in bronchodilation. All these effects were directly related to the MOE content in honokiol and magnolol. In conclusion, the properties of MOE highlighted here strongly encourage its application as dietary supplement in the treatment of airway diseases.
对于支持气道疾病治疗的膳食补充剂，厚朴（木兰科）的使用可能具有临床意义。两种市售的树皮提取物（厚朴提取物[MOE]）通过高效液相色谱法（HPLC）结合紫外检测进行了和厚朴酚和厚朴酚含量的定量分析。研究了 MOE 及其参考化合物本身对一些与气道疾病相关的靶标的影响（抗菌和肺及气管松弛活性）。结果表明，MOE 对金黄色葡萄球菌、铜绿假单胞菌和肺炎链球菌具有良好的抗菌活性。这伴随着平滑肌松弛和抗痉挛活性，可能是由于其同时调节不同靶标的能力，如参与支气管扩张的 H-、β-和毒蕈碱受体和 L 型钙通道。所有这些作用都与 MOE 中厚朴酚和和厚朴酚的含量直接相关。总之，这里强调的 MOE 的特性强烈鼓励将其作为膳食补充剂应用于气道疾病的治疗。
