Ly Hinh
Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
J Med Virol. 2023 Mar;95(3):e28636. doi: 10.1002/jmv.28636.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to diverse clinical manifestations and pathologies that involve multiple organs. Even though the disease severity is manifested mainly in the respiratory tract, which is the primary target of SARS-CoV-2 infection, acute kidney injury in the form of acute tubular necrosis has also been noted in some COVID-19 cases. It is not entirely clear whether renal cells can be infected by the virus that might be involved in acute kidney disorder. In a recent publication by Radovic and colleagues, that has been selected as the editor's choice paper published in the Journal of Medical Virology, the authors provided strong histopathological and immunofluorescence evidence of SARS-CoV-2 infection and tissue injury of renal parenchymal and tubular epithelial cells, which strongly suggest an active viral replication in the kidney of some severe and fatal COVID-19 cases, and to a lesser extent, a potential role for innate immune cells in viral infection and renal disease pathogenesis.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染可导致涉及多个器官的多种临床表现和病理变化。尽管疾病严重程度主要表现在呼吸道，而呼吸道是SARS-CoV-2感染的主要靶器官，但在一些新冠肺炎病例中也发现了以急性肾小管坏死形式出现的急性肾损伤。目前尚不完全清楚肾细胞是否会被可能参与急性肾脏疾病的病毒感染。在Radovic及其同事最近发表的一篇论文中（该论文被选为发表在《医学病毒学杂志》上的编辑推荐文章），作者提供了强有力的组织病理学和免疫荧光证据，证明SARS-CoV-2感染以及肾实质和肾小管上皮细胞的组织损伤，这强烈表明在一些重症和致命的新冠肺炎病例的肾脏中存在活跃的病毒复制，并且在较小程度上，固有免疫细胞在病毒感染和肾脏疾病发病机制中可能发挥作用。
