Blachut Dominika, Przywara-Chowaniec Brygida, Harpula Jan, Tomasik Andrzej, Nowalany-Kozielska Ewa, Morawiec Beata
nd Department of Cardiology, Medical University of Silesia in Katowice, Zabrze, Poland.
Arch Rheumatol. 2022 Sep 20;37(4):495-503. doi: 10.46497/ArchRheumatol.2022.9255. eCollection 2022 Dec.
This study aims to assess variables concerning arterial stiffness including carotid-femoral pulse wave velocity, carotid-radial pulse wave velocity, ankle-brachial index, and the advancement of atherosclerosis development.
Between October 2016 and December 2020, a total of 43 consecutive patients with systemic lupus erythematosus (SLE) (4 males, 39 females; mean age: 57±8 years; range, 42 to 65 years) were prospectively included in the study. All data were compared between the group treated with glucocorticoids and that not treated with these agents.
The study group consisted of 43 patients with SLE, while 22 (51%) patients were treated with glucocorticoids. The mean duration of SLE was 12.3±5.3 years. Patients treated with glucocorticoids had lower values of ankle-brachial index compared to those who were not treated with glucocorticoids (p=0.041), although the values were within the range. A similar situation was reported for the carotid-femoral artery pulse wave velocity (p=0.032). However, carotid-radial artery pulse wave velocity was not significantly different between both groups (p=0.12).
Properly selected therapy is important in the prevention of CVD.
本研究旨在评估与动脉僵硬度相关的变量，包括颈股脉搏波速度、颈桡脉搏波速度、踝臂指数以及动脉粥样硬化发展进程。
2016年10月至2020年12月期间，共有43例连续的系统性红斑狼疮（SLE）患者（4例男性，39例女性；平均年龄：57±8岁；范围42至65岁）被前瞻性纳入本研究。对所有数据在接受糖皮质激素治疗的组和未接受这些药物治疗的组之间进行比较。
研究组由43例SLE患者组成，其中22例（51%）患者接受了糖皮质激素治疗。SLE的平均病程为12.3±5.3年。与未接受糖皮质激素治疗的患者相比，接受糖皮质激素治疗的患者踝臂指数值较低（p=0.041），尽管这些值仍在正常范围内。颈股动脉脉搏波速度也有类似情况（p=0.032）。然而，两组之间颈桡动脉脉搏波速度无显著差异（p=0.12）。
正确选择治疗方法对预防心血管疾病很重要。
