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急性人类免疫缺陷病毒患者中比克替拉韦诱导的伴有嗜酸性粒细胞增多和全身症状的药物反应

Bictegravir-Induced Drug Reaction With Eosinophilia and Systemic Symptoms in a Patient With Acute Human Immunodeficiency Virus.

作者信息

DiLorenzo Madeline A, Medrano Nicola, Chen Jason N, Bawany Fatima, Tran Duy C, Taunk Pulkit, Meehan Shane A, Pomeranz Miriam Keltz, Mgbako Ofole

机构信息

Division of Infectious Diseases and Immunology, Department of Medicine, NYU Langone Health, New York, New York, USA.

Department of Internal Medicine, NYU Langone Health, New York, New York, USA.

出版信息

Open Forum Infect Dis. 2023 Feb 8;10(3):ofad066. doi: 10.1093/ofid/ofad066. eCollection 2023 Mar.

DOI:10.1093/ofid/ofad066
PMID:36879628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9985146/
Abstract

Although drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with antiretrovirals, there are no published reports of bictegravir-induced DRESS. Bictegravir is recommended as first-line treatment for patients with human immunodeficiency virus (HIV). Recognition of DRESS, its skin manifestations, and potential complications is vital for appropriate care and management of acute HIV.

摘要

虽然伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）与抗逆转录病毒药物有关，但尚无关于比克替拉韦诱发DRESS的报道。比克替拉韦被推荐作为人类免疫缺陷病毒（HIV）患者的一线治疗药物。认识DRESS及其皮肤表现和潜在并发症对于急性HIV的恰当护理和管理至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3f9/9985146/70677bba8e20/ofad066f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3f9/9985146/70677bba8e20/ofad066f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3f9/9985146/70677bba8e20/ofad066f1.jpg

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本文引用的文献

1
Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS)/Drug-Induced Hypersensitivity Syndrome (DiHS)-Readdressing the DReSS.伴嗜酸性粒细胞增多和全身症状的药物反应（DReSS）/药物性超敏反应综合征（DiHS）——重新审视DReSS
Biomedicines. 2022 Apr 26;10(5):999. doi: 10.3390/biomedicines10050999.
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Patch testing in drug reaction with eosinophilia and systemic symptoms (DRESS): A literature review.药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）中的斑贴试验：文献综述。
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Meta-Analysis of Efficacy and Safety of Coformulated Bictegravir, Emtricitabine, and Tenofovir Alafenamide Among People Living with HIV.
比克替拉韦、恩曲他滨和替诺福韦艾拉酚胺复方制剂在HIV感染者中的疗效和安全性的Meta分析
Infect Dis Ther. 2021 Sep;10(3):1331-1346. doi: 10.1007/s40121-021-00449-z. Epub 2021 May 11.
4
A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud's Of The Tongue.一例与舌部雷诺现象相关的替诺福韦诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征的独特病例。
Int J Gen Med. 2019 Oct 23;12:381-385. doi: 10.2147/IJGM.S215511. eCollection 2019.
5
Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019.药物诱导的超敏反应综合征（DiHS）/伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）：2019 年的更新。
Allergol Int. 2019 Jul;68(3):301-308. doi: 10.1016/j.alit.2019.03.006. Epub 2019 Apr 16.
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Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms severity score: A useful tool for assessing disease severity and predicting fatal cytomegalovirus disease.药物诱导的超敏反应/伴有嗜酸性粒细胞增多和全身症状的药物反应严重程度评分：评估疾病严重程度和预测致命性巨细胞病毒病的有用工具。
J Am Acad Dermatol. 2019 Mar;80(3):670-678.e2. doi: 10.1016/j.jaad.2018.08.052. Epub 2018 Sep 18.
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Br J Dermatol. 2013 Nov;169(5):1071-80. doi: 10.1111/bjd.12501.