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使用合成代谢雄激素类固醇导致的急性呼吸窘迫综合征、弥漫性肺泡出血和心包积液:医学教育中的法律与伦理政策

ARDS, Diffuse Alveolar Hemorrhage and Pericardial Effusion due to Anabolic-Androgenic Steroids Consumption: Legal and Ethical Policy in Medical Education.

作者信息

Abdi Mohammad, Lotfolahi Zahra, Zareie Maryam, Saeidi Mohammad, Amini Kourosh, Torkmandi Hojjat, Ghodrati Samad

机构信息

Department of Emergency and Critical Care, Faculty of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran.

Department of Medical Education, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Tanaffos. 2022 Feb;21(2):239-248.

PMID:36879726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9985117/
Abstract

Anabolic-androgenic steroids (AAS) are one of the ingredients of herbal and dietary supplements that are popular among sports trainers. AAS abuse predisposes everyone to several complications. Reviews of the literature on AAS users have shown mainly skin, renal, and hepatic complications. In this case report, we presented a case with simultaneous complications, including diffuse alveolar hemorrhage (DAH), acute respiratory distress syndrome (ARDS), pericardial effusion, gastrointestinal bleeding (GIB), and acute kidney injury (AKI). Given the potential for lethal complications and the consequences of ethical, civil, and criminal law, it seems that specific policies will be considered for the use of bodybuilding drugs. It is also suggested that this approach be added as a new part of the medical curriculum. Also, ARDS and DAH are unreported side effects in other studies, which is suggested to be considered by specialists.

摘要

合成代谢雄激素类固醇(AAS)是运动训练师中流行的草药和膳食补充剂成分之一。滥用AAS会使每个人都易患多种并发症。对AAS使用者的文献综述主要显示了皮肤、肾脏和肝脏并发症。在本病例报告中,我们展示了一例同时出现多种并发症的病例,包括弥漫性肺泡出血(DAH)、急性呼吸窘迫综合征(ARDS)、心包积液、胃肠道出血(GIB)和急性肾损伤(AKI)。鉴于存在致命并发症的可能性以及伦理、民法和刑法方面的后果,似乎将考虑针对使用健美药物制定具体政策。还建议将这种方法作为医学课程的新部分添加进去。此外,ARDS和DAH在其他研究中未被报告为副作用,建议专家予以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a281/9985117/a11501c7f1c9/Tanaffos-21-239-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a281/9985117/c57cdb253c19/Tanaffos-21-239-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a281/9985117/91eea9c4e290/Tanaffos-21-239-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a281/9985117/a11501c7f1c9/Tanaffos-21-239-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a281/9985117/c57cdb253c19/Tanaffos-21-239-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a281/9985117/91eea9c4e290/Tanaffos-21-239-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a281/9985117/a11501c7f1c9/Tanaffos-21-239-g003.jpg

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ARDS, Diffuse Alveolar Hemorrhage and Pericardial Effusion due to Anabolic-Androgenic Steroids Consumption: Legal and Ethical Policy in Medical Education.使用合成代谢雄激素类固醇导致的急性呼吸窘迫综合征、弥漫性肺泡出血和心包积液:医学教育中的法律与伦理政策
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本文引用的文献

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Kidney disease associated with androgenic-anabolic steroids and vitamin supplements abuse: Be aware!滥用雄激素-合成代谢类固醇和维生素补充剂与肾脏疾病相关:提高警惕!
Nefrologia (Engl Ed). 2020 Jan-Feb;40(1):26-31. doi: 10.1016/j.nefro.2019.06.003. Epub 2019 Oct 1.
2
Anabolic androgenic steroid-induced acute myocardial infarction with multiorgan failure.合成代谢雄激素类固醇诱导的急性心肌梗死伴多器官功能衰竭。
Proc (Bayl Univ Med Cent). 2018 May 15;31(3):334-336. doi: 10.1080/08998280.2018.1460130. eCollection 2018 Jul.
3
Prevalence, Attitude, Knowledge, and Practice of Anabolic Androgenic Steroid (AAS) Use Among Gym Participants.
健身参与者中合成代谢雄激素类固醇(AAS)使用的流行情况、态度、知识和行为
Mater Sociomed. 2018 Mar;30(1):49-52. doi: 10.5455/msm.2018.30.49-52.
4
Do anabolic-androgenic steroids have performance-enhancing effects in female athletes? anabolic-androgenic steroids 是否对女性运动员有提高运动表现的效果?
Mol Cell Endocrinol. 2018 Mar 15;464:56-64. doi: 10.1016/j.mce.2017.07.010. Epub 2017 Jul 12.
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Diffuse Alveolar Hemorrhage in Autoimmune Diseases.自身免疫性疾病中的弥漫性肺泡出血
Curr Rheumatol Rep. 2017 May;19(5):27. doi: 10.1007/s11926-017-0651-y.
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Review of treatment for alopecia totalis and alopecia universalis.全秃和普秃的治疗回顾。
Int J Dermatol. 2017 Aug;56(8):801-810. doi: 10.1111/ijd.13612. Epub 2017 Apr 5.
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Anabolic steroid use.合成代谢类固醇的使用。
BMJ. 2016 Oct 13;355:i5023. doi: 10.1136/bmj.i5023.
8
Severe Cholestasis and Bile Acid Nephropathy From Anabolic Steroids Successfully Treated With Plasmapheresis.血浆置换成功治疗合成代谢类固醇所致的严重胆汁淤积和胆汁酸肾病
ACG Case Rep J. 2016 Jan 20;3(2):133-5. doi: 10.14309/crj.2016.24. eCollection 2016 Jan.
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Recruitment to doping and help-seeking behavior of eight female AAS users.八名女性合成代谢类固醇使用者的兴奋剂使用招募情况及求助行为
Subst Abuse Treat Prev Policy. 2016 Mar 5;11:11. doi: 10.1186/s13011-016-0056-3.
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