College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, P. R. China.
J Mater Chem B. 2023 Mar 22;11(12):2733-2744. doi: 10.1039/d3tb00170a.
Chemoimmunotherapy is an effective method to treat cancer, and thus various vehicles have been constructed to co-deliver immune agents and anticancer drugs. But the immune induction process is highly susceptible to the influence of the material itself. To avoid immune reactions by the materials of delivery systems, herein, a new kind of zwitterionic cryogels (SH cryogels) with extremely low immunogenicity was prepared for chemoimmunotherapy of cancer. Their macroporous structure enabled the SH cryogels to have good compressibility and be injected through a conventional syringe. The loaded chemotherapeutic drugs and immune adjuvants were accurately, locally and long-termly released in the vicinity of tumors, enhancing the outcome of tumor therapy and minimizing the damage caused by the chemotherapeutic drugs to other organ tissues. tumor treatment experiments indicated that chemoimmunotherapy using the SH cryogel platform could inhibit the growth of breast cancer tumors to the greatest extent. Furthermore, macropores of SH cryogels supported cells to move freely in the cryogels, which could promote the dendritic cells to capture the produced tumor antigens and present them to T cells. The ability to act as cradles for cell infiltration made the SH cryogels promising for applications as vaccine platforms.
化疗免疫治疗是治疗癌症的一种有效方法，因此构建了各种载体来共同递送免疫剂和抗癌药物。但是免疫诱导过程极易受到材料本身的影响。为了避免给药系统材料引起的免疫反应，本文制备了一种新型两性离子冷冻凝胶（SH 冷冻凝胶）用于癌症的化疗免疫治疗，其具有极低的免疫原性。其大孔结构使 SH 冷冻凝胶具有良好的可压缩性，并可通过常规注射器进行注射。负载的化疗药物和免疫佐剂在肿瘤附近准确、局部和长期释放，增强了肿瘤治疗效果，并最大限度地减少了化疗药物对其他器官组织的损伤。肿瘤治疗实验表明，使用 SH 冷冻凝胶平台进行的化疗免疫治疗可以最大限度地抑制乳腺癌肿瘤的生长。此外，SH 冷冻凝胶的大孔支持细胞在冷冻凝胶中自由移动，这可以促进树突状细胞捕获产生的肿瘤抗原并将其呈递给 T 细胞。作为细胞浸润的摇篮，SH 冷冻凝胶有望成为疫苗平台的应用。
