College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, P. R. China.
Biomacromolecules. 2024 Jul 8;25(7):4394-4405. doi: 10.1021/acs.biomac.4c00442. Epub 2024 Jun 10.
Combination immunotherapy is being increasingly explored for cancer treatment, leading to various vector materials for the codelivery of immune agents and drugs. However, current tumor vaccines exhibit poor immunogenicity, severely compromising their therapeutic efficacy. Herein, an injectable hydrogel was developed based on dopamine (DA) and Panax notoginseng polysaccharide (PNPS) loaded with hair microparticles (HMPs) to enhance the immunogenicity of tumor vaccines. Photothermal effects of incorporated HMPs can trigger immunogenic cancer cell death and the release of abundant autologous tumor antigens, which are captured by catechol groups. Concomitant breakdown of PNPS recruits and activates dendritic cells (DCs). The macroporous structure of cryogels allows immune cell infiltration and interaction with antigens adsorbed on PNPS and DA cryogels (PD cryogels), thereby provoking potent cytotoxic T-cell responses. Hence, PD cryogels enabling cell infiltration and accelerated DC maturation may serve as a therapeutic vaccination platform against cancer.
免疫联合治疗正被越来越多地探索应用于癌症治疗，由此产生了各种载体材料来共递送免疫制剂和药物。然而，目前的肿瘤疫苗表现出较差的免疫原性，严重影响了它们的治疗效果。在此，我们基于负载有发状微粒（HMPs）的多巴胺（DA）和三七多糖（PNPS）开发了一种可注射水凝胶，以增强肿瘤疫苗的免疫原性。所掺入的 HMPs 的光热效应可以引发免疫原性的癌细胞死亡，并释放大量的自体肿瘤抗原，这些抗原被儿茶酚基团捕获。同时，PNPS 的崩解会募集并激活树突状细胞（DCs）。冷冻凝胶的大孔结构允许免疫细胞浸润，并与吸附在 PNPS 和 DA 冷冻凝胶（PD 冷冻凝胶）上的抗原相互作用，从而引发强烈的细胞毒性 T 细胞反应。因此，能够促进细胞浸润和加速 DC 成熟的 PD 冷冻凝胶可以作为一种治疗性癌症疫苗接种平台。
