School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China.
Shanghai BIOS Technology Co., Ltd., 659 Maoyuan Road, Fengxian District, Shanghai 201418, China.
Org Lett. 2023 Mar 17;25(10):1673-1677. doi: 10.1021/acs.orglett.3c00307. Epub 2023 Mar 7.
A photoredox/nickel dual catalytic protocol for the regioselective three-component carboacylation of alkenes with tertiary and secondary alkyltrifluoroborates as well as acyl chlorides is described. This redox-neutral protocol can be applied to the rapid synthesis of ketones with high diversity and complexity via a radical relay process. Many functional groups, allowing for various commercially available acyl chlorides, alkyltrifluoroborates, and alkenes, are tolerated under these mild conditions.
本文描述了一种光氧化还原/镍双催化的区域选择性三组分烯烃与叔烷基和仲烷基三氟硼酸盐以及酰氯的碳酰化反应。该还原中性的反应可以通过自由基接力过程应用于酮的快速合成，具有高多样性和复杂性。许多功能基团在这些温和的条件下都能得到容忍，允许使用各种市售的酰氯、烷基三氟硼酸盐和烯烃。
