Jin Shengzhou, Wang Lanfen, Jia Yinggang, Ma Wenbo, Wang Dingyi
Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, China.
College of Sciences, Northeastern University, Shenyang 110004, China.
Molecules. 2024 Sep 10;29(18):4295. doi: 10.3390/molecules29184295.
Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of these substrates remains relatively limited, particularly due to their incompatibility with sensitive functional groups. Herein, we report a Ni-catalyzed three-component 1,2-carboacylation of alkenes, which activates secondary/tertiary alkyl bromides. This method offers significant advantages: simplicity of operation, ready availability of substrates, and broad substrate applicability. A series of experimental studies have helped clarify the key mechanistic pathways involved in this cascade reaction.
酮类化合物存在于许多具有重要生物学意义的分子中，因此需要开发新的方法来合成这些结构，这是有机合成中的一项关键任务。过渡金属催化已被证明是合成酮类化合物的有效方法。然而，这些底物的范围仍然相对有限，特别是因为它们与敏感官能团不兼容。在此，我们报道了一种镍催化的烯烃1,2-碳酰化三组分反应，该反应可活化仲/叔烷基溴。该方法具有显著优势：操作简单、底物易于获得且底物适用性广泛。一系列实验研究有助于阐明该串联反应中涉及的关键机理途径。
