College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P. R. China.
Jiangxi Time Chemical Company, Ltd., Fuzhou, Fujian 344800, P. R. China.
Org Lett. 2023 Mar 17;25(10):1782-1786. doi: 10.1021/acs.orglett.3c00559. Epub 2023 Mar 8.
A metal-free photosensitized three-component reaction of oxime esters, alkenes, and DABCO·(SO) was developed. This protocol could accommodate a wide substrate scope, including activated and unactivated alkenes and aryl and aliphatic carboxylic acid oxime esters, delivering a broad range of β-amino sulfones in moderate to high yields. The insertion of SO as a linker moiety allows the manipulation of the functionality in the reaction process, expanding the utility of oxime esters as bifunctional reagents.
开发了一种无金属的光敏三组分反应，涉及肟酯、烯烃和 DABCO·（SO）。该方案可适应广泛的底物范围，包括活化和未活化的烯烃以及芳基和脂肪族羧酸肟酯，以中等至高产率提供广泛的β-氨基砜。SO 的插入作为连接基团允许在反应过程中对功能进行操作，从而扩大肟酯作为双功能试剂的用途。
