Xiao Ze-Long, Xie Zhen-Zhen, Yuan Chu-Ping, Deng Ke-Yi, Chen Kai, Chen Hong-Bin, Xiang Hao-Yue, Yang Hua
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China.
Xiangjiang Laboratory, Changsha 410205, China.
Org Lett. 2024 Mar 15;26(10):2108-2113. doi: 10.1021/acs.orglett.4c00432. Epub 2024 Mar 5.
A metal-free photosensitized 1,2-imino-sulfamoylation of olefins by employing a tailor-made sulfamoyl carbamate as the difunctionalization reagent has been established. This protocol exhibits versatility across a broad substrate scope, including aryl and aliphatic alkenes, leading to the synthesis of diverse β-imino sulfonamides in moderate to good yields. This method is characterized by its metal-free reaction system, mild reaction conditions, excellent regioselectivity, and high atom economy, serving as a promising platform for the preparation of β-amino sulfonamide-containing molecules, particularly in the context of drug discovery.
通过使用定制的氨磺酰基氨基甲酸酯作为双官能化试剂，建立了一种无金属光催化烯烃的1,2-亚氨基-氨磺酰化反应。该方案在广泛的底物范围内具有通用性，包括芳基和脂肪族烯烃，能够以中等至良好的产率合成各种β-亚氨基磺酰胺。该方法的特点是无金属反应体系、温和的反应条件、优异的区域选择性和高原子经济性，是制备含β-氨基磺酰胺分子的有前景的平台，特别是在药物发现领域。
