College of Sport Science, Sungkyunkwan University, Suwon, Republic of Korea.
College of Sport Science, Sungkyunkwan University, Suwon, Republic of Korea.
Physiol Behav. 2023 May 15;264:114145. doi: 10.1016/j.physbeh.2023.114145. Epub 2023 Mar 6.
Physical exercise has been recommended as a non-pharmacologic treatment for delaying the onset or slowing the progression of Alzheimer's disease (AD). The therapeutic potential of exercise training-induced changes in symbiotic gut microbiota against AD neuropathology is not well understood, yet. This study investigated the effects of a 20-week forced treadmill exercise program on the makeup of the gut microbiota, the integrity of the blood-brain barrier (BBB), and the development of AD-like cognitive deficits and neuropathology in triple transgenic AD mice. Our findings show that forced treadmill running causes symbiotic changes in the gut microbiota, such as increased Akkermansia muciniphila and decreased Bacteroides species, as well as increased BBB-related protein expression and reduced AD-like cognitive impairments and neuropathology progression. The current findings of this animal study suggest that the interaction between the gut microbiota and the brain, possibly via the BBB, is responsible for exercise training-induced cognitive benefits and alleviation of AD pathology.
体育锻炼已被推荐为一种非药物治疗方法，可延缓阿尔茨海默病（AD）的发病或减缓其进展。然而，运动训练引起的共生肠道微生物群变化对 AD 神经病理学的治疗潜力尚未得到很好的理解。本研究调查了 20 周强制跑步机运动方案对肠道微生物群组成、血脑屏障（BBB）完整性以及三转基因 AD 小鼠出现 AD 样认知缺陷和神经病理学的影响。我们的研究结果表明，强制跑步机跑步会导致共生肠道微生物群发生变化，例如阿克曼氏菌（Akkermansia muciniphila）增加和拟杆菌（Bacteroides）减少，以及 BBB 相关蛋白表达增加和 AD 样认知障碍及神经病理学进展减少。这项动物研究的结果表明，肠道微生物群与大脑之间的相互作用可能通过 BBB 负责运动训练引起的认知益处和 AD 病理学的缓解。
