Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China.
Branch of National Clinical Research Center for Metabolic Disease, Hubei, People's Republic of China.
BMC Cardiovasc Disord. 2023 Mar 8;23(1):120. doi: 10.1186/s12872-023-03126-w.
Central obesity is associated with an increased risk of hypertension in the general population. However, little is known regarding the potential relationship between central obesity and the risk of hypertension among adults with a normal body mass index (BMI). Our aim was to assess the risk of hypertension among individuals with normal weight central obesity (NWCO) in a large Chinese population.
We identified 10 719 individuals aged 18 years or older from the China Health and Nutrition Survey 2015. Hypertension was defined by blood pressure measurements, physician diagnosis, or the use of antihypertensive treatment. Multivariable logistic regression was used to assess the association of obesity patterns, defined by BMI, waist circumference (WC) and waist hip ratio (WHR), with hypertension after adjusting for confounding factors.
The patients' mean age was 53.6 ± 14.5 years, and 54.2% were women. Compared with individuals with a normal BMI but no central obesity, subjects with NWCO had a greater risk of hypertension (WC: OR, 1.49, 95% CI 1.14-1.95; WHR: OR, 1.33, 95% CI 1.08-1.65). Overweight-obese subjects with central obesity demonstrated the highest risk of hypertension after adjustment for potential confounders (WC: OR, 3.01, 95% CI 2.59-3.49; WHR: OR, 3.08, CI 2.6-3.65). Subgroup analyses showed that the combination of BMI with WC had similar findings to the overall population except for female and nonsmoking persons; when BMI was combined with WHR, a significant association of NWCO with hypertension was observed only in younger persons and nondrinkers.
Central obesity, as defined by WC or WHR, is associated with an increased risk of hypertension in Chinese adults with normal BMI, highlighting the need to combine measures in obesity-related risk assessment.
中心性肥胖与普通人群高血压风险增加相关。然而，对于正常体重中心性肥胖（NWCO）成年人中中心性肥胖与高血压风险之间的潜在关系知之甚少。我们的目的是评估中国庞大人群中 NWCO 个体患高血压的风险。
我们从 2015 年中国健康与营养调查中确定了 10719 名年龄在 18 岁及以上的个体。高血压通过血压测量、医生诊断或使用抗高血压治疗来定义。多变量逻辑回归用于评估 BMI、腰围（WC）和腰臀比（WHR）定义的肥胖模式与调整混杂因素后高血压的关系。
患者的平均年龄为 53.6±14.5 岁，54.2%为女性。与 BMI 正常但无中心性肥胖的个体相比，NWCO 个体患高血压的风险更高（WC：OR，1.49，95%CI 1.14-1.95；WHR：OR，1.33，95%CI 1.08-1.65）。调整潜在混杂因素后，中心性肥胖超重肥胖患者患高血压的风险最高（WC：OR，3.01，95%CI 2.59-3.49；WHR：OR，3.08，CI 2.6-3.65）。亚组分析表明，BMI 与 WC 结合的结果与总体人群相似，除女性和不吸烟者外；当 BMI 与 WHR 结合时，NWCO 与高血压的显著相关性仅在年轻人群和不饮酒者中观察到。
WC 或 WHR 定义的中心性肥胖与中国正常 BMI 成年人高血压风险增加相关，这强调了在肥胖相关风险评估中需要结合多种指标。
