Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Traditional Medicine, Chang Gung University, Taoyuan, Taiwan.
J Biochem Mol Toxicol. 2023 May;37(5):e23323. doi: 10.1002/jbt.23323. Epub 2023 Mar 8.
With the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much. Methotrexate (MTX) plays an essential role in the success of children's ALL treatment. Since hepatotoxicity is commonly reported in individuals treated with intravenous or oral MTX, our study further examined the hepatic effect following intrathecal MTX treatment, which is an essential treatment for leukemia patients. Specifically, we examined the pathogenesis of MTX hepatotoxicity in young rats and explored the impact of melatonin treatment in protection against MTX hepatotoxicity. Successfully, we found that melatonin was able to protect against MTX hepatotoxicity.
随着儿童急性淋巴细胞白血病 (ALL) 治疗水平的提高，儿童 ALL 的生存率有了很大的提高。甲氨蝶呤 (MTX) 在儿童 ALL 治疗的成功中起着至关重要的作用。由于静脉或口服 MTX 治疗的个体常报告有肝毒性，我们的研究进一步检查了鞘内 MTX 治疗后的肝脏效应，这是白血病患者的一种重要治疗方法。具体来说，我们研究了 MTX 肝毒性在幼鼠中的发病机制，并探讨了褪黑素治疗对 MTX 肝毒性的保护作用。结果发现，褪黑素能够预防 MTX 肝毒性。
