酪蛋白激酶 2 介导 HIV 和阿片类药物诱导的基底神经节中 TAR DNA 结合蛋白 43 的病理性磷酸化。
Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.
机构信息
Pharmacology and Toxicology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA.
Pathology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA.
出版信息
ASN Neuro. 2023 Jan-Dec;15:17590914231158218. doi: 10.1177/17590914231158218.
Abstract
HIV/HIV-1 Tat and morphine independently increase pathologic phosphorylation of TAR DNA binding protein 43 in the striatum. HIV- and opioid-induced pathologic phosphorylation of TAR DNA binding protein 43 may involve enhanced CK2 activity and protein levels.
摘要
HIV/HIV-1 Tat 和吗啡可独立增加纹状体中 TAR DNA 结合蛋白 43 的病理性磷酸化。HIV 和阿片类药物诱导的 TAR DNA 结合蛋白 43 的病理性磷酸化可能涉及 CK2 活性和蛋白水平的增强。
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