Grote T H, Hainsworth J D
Division of Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Arch Intern Med. 1987 Dec;147(12):2212-3.
This report describes a 49-year-old man with hypercalcemia and seminoma. His serum calcitriol (1,25-dihydroxy-vitamin D) level was markedly elevated. Additional endocrine evaluation revealed a normal serum phosphate level, hypercalciuria, and normal serum levels of immunoreactive parathyroid hormone. Serum calcium and calcitriol levels returned to normal following partial resection and successful combination chemotherapy. The association of hypercalcemia and elevated serum calcitriol levels has been previously described in a few patients with malignant lymphoma, but, to our knowledge, not in patients with solid tumors. The mechanism of hypercalcemia in this patient is not proved, but available evidence suggests calcitriol as the mediator.
本报告描述了一名患有高钙血症和精原细胞瘤的49岁男性。他的血清骨化三醇（1,25 - 二羟维生素D）水平显著升高。进一步的内分泌评估显示血清磷酸盐水平正常、高钙尿症以及免疫反应性甲状旁腺激素血清水平正常。部分切除并成功进行联合化疗后，血清钙和骨化三醇水平恢复正常。高钙血症与血清骨化三醇水平升高之间的关联此前在少数恶性淋巴瘤患者中已有描述，但据我们所知，在实体瘤患者中尚未有此报道。该患者高钙血症的机制尚未得到证实，但现有证据表明骨化三醇是介导因素。
