Department of Respiratory and Critical Medicine, Peking University Third Hospital, Beijing, People's Republic of China.
Department of Respiratory and Critical Medicine, Peking University International Hospital, Beijing, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2023 Mar 2;18:189-206. doi: 10.2147/COPD.S392349. eCollection 2023.
Both COPD and interstitial lung abnormalities (ILAs) are conditions associated with smoking and age. The impact of coexistent ILAs on the manifestations and outcomes of COPD or emphysema awaits evaluation.
We searched PubMed and Embase using Medical Subject Headings terms in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Eleven studies were included in the review. The sample size of the studies ranged from 30 to 9579. ILAs were reported in 6.5% to 25.7% of the patients with COPD/emphysema, higher than that reported in the general populations. COPD/emphysema patients with ILAs were older, mostly male, and had a higher smoking index than those without ILAs. Hospital admission and mortality were increased in COPD patients with ILAs compared to those without ILAs, whereas the frequency of COPD exacerbations was discrepant in 2 of the studies. The FEV and FEV% predicted tended to be higher in the group with ILAs, but not significantly in most of the studies.
ILAs were more frequent in subjects with COPD/emphysema than in the general population. ILAs may have a negative impact on hospital admission and mortality of COPD/emphysema. The impact of ILAs on lung functions and exacerbations of COPD/emphysema was discrepant in these studies. Further prospective studies are warranted to provide high-quality evidence of the association and interaction between COPD/emphysema and ILAs.
COPD 和肺间质异常（ILAs）都是与吸烟和年龄相关的疾病。共存的 ILAs 对 COPD 或肺气肿的表现和结果的影响有待评估。
我们根据系统评价和荟萃分析的首选报告项目，使用 PubMed 和 Embase 中的医学主题词进行了搜索。
共有 11 项研究纳入了综述。这些研究的样本量范围从 30 到 9579 例。在 COPD/肺气肿患者中，ILAs 的报告比例为 6.5%至 25.7%，高于一般人群的报告比例。与无 ILAs 的 COPD/肺气肿患者相比，有 ILAs 的患者年龄更大、多数为男性，且吸烟指数更高。与无 ILAs 的患者相比，有 ILAs 的 COPD 患者的住院率和死亡率增加，而在其中 2 项研究中 COPD 恶化的频率存在差异。在大多数研究中，有 ILAs 的患者的 FEV 和 FEV%预测值较高，但无显著差异。
在 COPD/肺气肿患者中，ILAs 的发生率高于一般人群。ILAs 可能对 COPD/肺气肿的住院率和死亡率产生负面影响。在这些研究中，ILAs 对 COPD/肺气肿的肺功能和恶化的影响存在差异。需要进一步的前瞻性研究提供 COPD/肺气肿与 ILAs 之间的关联和相互作用的高质量证据。
