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Avacopan, a selective C5a receptor antagonist, for anti-neutrophil cytoplasmic antibody-associated vasculitis.阿伐考潘,一种选择性 C5a 受体拮抗剂,用于治疗抗中性粒细胞胞质抗体相关性血管炎。
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Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.口服C5a受体抑制剂阿伐考泮辅助治疗抗中性粒细胞胞浆抗体相关性血管炎患者。
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2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.2021 年美国风湿病学会/血管炎基金会抗中性粒细胞胞浆抗体相关性血管炎治疗指南。
Arthritis Rheumatol. 2021 Aug;73(8):1366-1383. doi: 10.1002/art.41773. Epub 2021 Jul 8.
2
ANCA-Associated Vasculitis: An Update.抗中性粒细胞胞浆抗体相关血管炎:最新进展
J Clin Med. 2021 Apr 1;10(7):1446. doi: 10.3390/jcm10071446.
3
Avacopan for the Treatment of ANCA-Associated Vasculitis.阿伐考潘治疗抗中性粒细胞胞浆抗体相关性血管炎。
N Engl J Med. 2021 Feb 18;384(7):599-609. doi: 10.1056/NEJMoa2023386.
4
Adjunctive Treatment With Avacopan, an Oral C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.口服C5a受体抑制剂阿伐考泮辅助治疗抗中性粒细胞胞浆抗体相关性血管炎患者。
ACR Open Rheumatol. 2020 Nov;2(11):662-671. doi: 10.1002/acr2.11185. Epub 2020 Oct 31.
5
Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function.小分子 C5aR1 抑制剂在人细胞中的药理学特征揭示了其信号转导和功能的偏向活性。
Biochem Pharmacol. 2020 Oct;180:114156. doi: 10.1016/j.bcp.2020.114156. Epub 2020 Jul 17.
6
Evaluation of the Safety and Efficacy of Avacopan, a C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine: Protocol for a Randomized, Double-Blind, Active-Controlled, Phase 3 Trial.在接受利妥昔单抗或环磷酰胺/硫唑嘌呤联合治疗的抗中性粒细胞胞浆抗体相关性血管炎患者中评估C5a受体抑制剂阿伐库潘的安全性和有效性:一项随机、双盲、活性对照3期试验方案
JMIR Res Protoc. 2020 Apr 7;9(4):e16664. doi: 10.2196/16664.
7
Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis.C5a受体抑制剂阿伐库潘治疗抗中性粒细胞胞浆抗体相关性血管炎的随机试验
J Am Soc Nephrol. 2017 Sep;28(9):2756-2767. doi: 10.1681/ASN.2016111179. Epub 2017 Apr 11.
8
Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.基于临床前评估和随机1期临床研究对CCX168(一种强效且选择性口服补体5a受体抑制剂)的药理学和药代动力学特性进行表征。
PLoS One. 2016 Oct 21;11(10):e0164646. doi: 10.1371/journal.pone.0164646. eCollection 2016.
9
EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis.EULAR/ERA-EDTA 关于抗中性粒细胞胞浆抗体相关性血管炎治疗的建议。
Ann Rheum Dis. 2016 Sep;75(9):1583-94. doi: 10.1136/annrheumdis-2016-209133. Epub 2016 Jun 23.

Avacopan.

作者信息

Levien Terri L, Baker Danial E

机构信息

Washington State University, Spokane, WA, USA.

出版信息

Hosp Pharm. 2023 Apr;58(2):134-142. doi: 10.1177/00185787221087187. Epub 2022 Apr 15.

DOI:10.1177/00185787221087187
PMID:36890951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9986577/
Abstract
摘要