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产前诊断对先天性心脏病新生儿病情演变的影响。

The Impact of Prenatal Diagnosis in the Evolution of Newborns with Congenital Heart Disease.

作者信息

Toma Daniela, Moldovan Elena, Gozar Liliana

机构信息

Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation, Targu Mures, Romania.

Department of Pediatrics, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures, Romania.

出版信息

J Crit Care Med (Targu Mures). 2023 Feb 8;9(1):6-11. doi: 10.2478/jccm-2023-0007. eCollection 2023 Jan.

Abstract

Congenital heart malformations are cardiac and/or vascular structural abnormalities that appear before birth, the majority of which can be detected prenatally. The latest data from the literature were reviewed, with reference to the degree of prenatal diagnosis regarding congenital heart malformations, as well as its impact on the preoperative evolution and implicitly on mortality. Studies with a significant number of enrolled patients were included in the research. Prenatal congenital heart malformations detection rates were different, depending on the period in which the study took place, the level of the medical center, as well as on the size of enrolled groups. Prenatal diagnosis in critical malformations such as hypoplastic left heart syndrome, transposition of great arteries and totally aberrant pulmonary venous drainage has proven its usefulness, allowing an early surgical intervention, thus ensuring improved neurological development, increasing the survival rate and decreasing the rate of subsequent complications. Sharing the experience and results obtained by each individual therapeutic center will definitely lead to drawing clear conclusions regarding the clinical contribution of congenital heart malformations prenatal detection.

摘要

先天性心脏畸形是指在出生前出现的心脏和/或血管结构异常,其中大多数可以在产前检测到。参考了有关先天性心脏畸形的产前诊断程度及其对术前病情发展以及对死亡率的潜在影响的文献最新数据。研究纳入了大量入组患者的研究。产前先天性心脏畸形的检出率各不相同,这取决于研究开展的时期、医疗中心的水平以及入组人群的规模。对于诸如左心发育不全综合征、大动脉转位和完全性肺静脉异位引流等严重畸形的产前诊断已证明其有用性,可进行早期手术干预,从而确保改善神经发育、提高生存率并降低后续并发症的发生率。分享各个治疗中心获得的经验和结果肯定会有助于就先天性心脏畸形产前检测的临床贡献得出明确结论。

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Genetics of Congenital Heart Disease.先天性心脏病的遗传学。
Biomolecules. 2019 Dec 16;9(12):879. doi: 10.3390/biom9120879.

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