School of Basic Medical Sciences, Nanchang University, Nanchang, China.
Clinical Medical Experimental Center, Nanchang University, Nanchang, China.
Front Endocrinol (Lausanne). 2023 Feb 20;14:1114463. doi: 10.3389/fendo.2023.1114463. eCollection 2023.
As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa.
作为新兴的有机污染物，全氟和多氟烷基物质（PFASs）因其环境持久性、普遍存在性、生物累积性和潜在毒性而引起了全球关注。已经证明，PFASs 可以在人体内积累，并导致多种不良健康后果。值得注意的是，PFASs 已在人类精液中被检测到，这对男性生育力构成了潜在威胁。本文综述了接触 PFASs 对男性生殖的毒性作用的证据，重点关注精子质量。流行病学研究表明，全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）等 PFASs 与人类精液参数呈负相关，包括精子计数、形态和活力。实验结果还证实，PFAS 暴露会导致睾丸和附睾损伤，从而损害精子发生和精子质量。PFASs 的生殖毒性机制可能涉及血睾屏障破坏、睾丸细胞凋亡、睾酮合成障碍、精子膜脂质组成改变、氧化应激和 Ca2+内流。总之，本综述强调了接触 PFASs 对人类精子的潜在威胁。
