塔拉罗内酯A - G，源自[具体来源未给出]的具有抗炎活性的α-吡喃二聚体及其生物合成途径。
Talarolactones A-G, α-Pyrone Dimers with Anti-inflammatory Activities from , and Their Biosynthetic Pathways.
作者信息
Li Qin, Zheng Meijia, Li Fengli, Li Yongqi, Chen Chunmei, Huang Zijian, Liu Junjun, Sun Weiguang, Ye Ying, Zhu Hucheng, Zhang Yonghui
机构信息
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
出版信息
Org Lett. 2023 Mar 17;25(10):1616-1621. doi: 10.1021/acs.orglett.2c04352. Epub 2023 Mar 9.
Talarolactones A-G (-), seven novel α-pyrone adducts with unprecedented scaffolds, together with two pairs of α-pyrone monomers [(±)- and (±)-)] were isolated from . Compounds - are highly modified α-pyrone dimers with a 4,7,7,8-tetrasubstitued 5,6,7,8-tetrahydro-2-chromen-2-one. Compounds and possessed a significant NO production inhibitory effect, with IC values of 2.3 ± 0.1 and 3.7 ± 0.3 μM, respectively. Plausible biosynthetic pathways were proposed and supported by the results of heterologous expression experiments.
从……中分离出了塔拉罗内酯A - G（-），七种具有前所未有的骨架的新型α-吡喃酮加合物，以及两对α-吡喃酮单体[（±）-和（±）-]。化合物-是具有4,7,7,8-四取代的5,6,7,8-四氢-2-色满-2-酮的高度修饰的α-吡喃酮二聚体。化合物和具有显著的一氧化氮产生抑制作用，IC值分别为2.3±0.1和3.7±0.3μM。提出了合理的生物合成途径，并得到了异源表达实验结果的支持。
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