Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Catania, Italy.
Methods Mol Biol. 2023;2651:131-141. doi: 10.1007/978-1-0716-3084-6_9.
The non-covalent interaction of achiral porphyrins with nucleic acids has been extensively studied, and various macrocycles have been indeed utilized as reporters of different sequences of DNA bases. Nevertheless, few studies have been published on the capability of these macrocycles to discriminate among the various nucleic acid conformations. Circular dichroism spectroscopy allowed to characterize the binding of several cationic and anionic mesoporphyrins and metallo derivatives with Z-DNA, in order to exploit the functionality of these systems as probes, storing system, and logic gate.
非手性卟啉与核酸的非共价相互作用已得到广泛研究，各种大环确实被用作不同 DNA 碱基序列的报告分子。然而，关于这些大环区分各种核酸构象的能力的研究很少。圆二色光谱允许表征几种阳离子和阴离子mesoporphyrins 和金属衍生物与 Z-DNA 的结合，以利用这些系统作为探针、存储系统和逻辑门的功能。
