视交叉上核注射血管加压素拮抗剂可改变食物摄入的昼夜节律。

Suprachiasmatic injection of a vasopressin antagonist modifies the circadian rhythm of food intake.

作者信息

Reghunandanan V, Badgaiyan R D, Marya R K, Maini B K

机构信息

Department of Physiology, Medical College, Haryana, India.

出版信息

Behav Neural Biol. 1987 Nov;48(3):344-51. doi: 10.1016/s0163-1047(87)90905-8.

DOI:10.1016/s0163-1047(87)90905-8

PMID:3689283

Abstract

To study the effect on the circadian feeding rhythm, injections of AVP and its antagonist were made into the suprachiasmatic nuclei (SCN) of rats after implanting cannulae into the bilateral SCN. Injections of arginine vasopressin (AVP) antagonist at the beginning of the light and dark phases disrupted the circadian rhythm of food intake while injections of AVP during the beginning of the light or dark phase did not disrupt the circadian rhythm. It may be concluded that endogenous vasopressin has a modulatory role in the mediation of the circadian feeding rhythm at SCN.

摘要

为研究对昼夜进食节律的影响，在将套管植入大鼠双侧视交叉上核（SCN）后，向SCN注射血管加压素（AVP）及其拮抗剂。在光照期和暗期开始时注射AVP拮抗剂会扰乱食物摄入的昼夜节律，而在光照期或暗期开始时注射AVP则不会扰乱昼夜节律。可以得出结论，内源性血管加压素在SCN介导昼夜进食节律中具有调节作用。