Reghunandanan V, Badgaiyan R D, Marya R K, Reghunandanan R, Maini B K
Department of Physiology, Medical College, Rohtak, Haryana Pin, India.
Chronobiol Int. 1989;6(2):123-9. doi: 10.3109/07420528909064622.
Effect of lithium injections through chronically implanted cannulae into the bilateral suprachiasmatic nuclei (SCN) on the circadian rhythm of food intake was investigated in the rat. It was observed that the circadian rhythm was disrupted by injections of lithium at the beginning of the light as well as the dark phase of the LD cycle. In either case the percentage of the food consumed during the 12-hr light period increased while that during the dark period decreased without any significant change in the total daily intake. Disruptions in the circadian rhythm of food intake failed to show any dose-response relation. Injections of saline into the SCN or lithium into the nearby SCN area did not produce a disruption of the circadian rhythm of food intake.
通过长期植入的套管向大鼠双侧视交叉上核（SCN）注射锂对食物摄入昼夜节律的影响进行了研究。观察到，在光暗循环的光照期和黑暗期开始时注射锂会扰乱昼夜节律。在这两种情况下，12小时光照期内消耗的食物百分比增加，而黑暗期内的百分比降低，每日总摄入量没有任何显著变化。食物摄入昼夜节律的扰乱未显示出任何剂量反应关系。向SCN注射生理盐水或向附近的SCN区域注射锂均未导致食物摄入昼夜节律的扰乱。
