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N-杂芳环的高效去芳构化反应方案，使用卤（I）络合催化剂。

Protocol for efficient dearomatization of N-heteroaromatics with halogen(I) complex catalyst.

机构信息

Institute for Molecular Science, Okazaki, Aichi 444-8787, Japan; SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi 444-8787, Japan.

Institute for Molecular Science, Okazaki, Aichi 444-8787, Japan.

出版信息

STAR Protoc. 2023 Mar 17;4(1):102140. doi: 10.1016/j.xpro.2023.102140. Epub 2023 Mar 9.

DOI:10.1016/j.xpro.2023.102140
PMID:36892997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10020682/
Abstract

In this protocol, we describe the application of a halogen(I) complex as a highly active non-metallic complex catalyst. Specifically, we present a detailed guide to synthesize the halogen(I) complex catalyst and utilize it as an anion-binding catalyst for the Mukaiyama-Mannich-type reaction of N-heteroaromatics such as pyridines. By utilizing a simple catalyst preparation approach and relatively low catalyst loading, the steps outlined in this protocol contribute to the rapid development of useful substances such as pharmaceuticals and functional materials. For complete details on the use and execution of this protocol, please refer to Oishi et al. (2022)..

摘要

在本方案中，我们介绍了卤（I）配合物作为一种高效的非金属配合物催化剂的应用。具体来说，我们提供了详细的合成卤（I）配合物催化剂的指南，并将其用作氮杂芳烃（如吡啶）的 Mukaiyama-Mannich 型反应的阴离子结合催化剂。通过采用简单的催化剂制备方法和较低的催化剂负载量，本方案中所述的步骤有助于快速开发药物和功能材料等有用物质。有关本方案使用和实施的完整详细信息，请参阅 Oishi 等人（2022 年）。

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