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智利慢性疼痛:非癌症慢性疼痛、纤维肌痛和神经性疼痛的首次流行报告及其相关因素。

Chronic pain in Chile: first prevalence report of noncancer chronic pain, fibromyalgia, and neuropathic pain and its associated factors.

机构信息

Departamento Reumatología, Pontificia Universidad Católica de Chile, Santiago, Chile.

Departamento Fisiología, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

Pain. 2023 Aug 1;164(8):1852-1859. doi: 10.1097/j.pain.0000000000002886. Epub 2023 Mar 9.

Abstract

Although we know chronic pain (CP) affects approximately 30% of people in developed countries, data from Latin America are scarce. Moreover, prevalence of specific CP conditions, such as chronic noncancer pain (CNCP), fibromyalgia (FM), and neuropathic pain (NP), is unknown. To estimate them in Chile, we prospectively enrolled 1945 participants (61.4% women and 38.6% men), aged 38 to 74 years, from an agricultural town who answered a Pain Questionnaire, the Fibromyalgia Survey Questionnaire, and Douleur Neuropathique 4 (DN4) to identify CNCP, FM, and NP, respectively. The estimated prevalence of CNCP was 34.7% (95% CI 32.6; 36.8), with an average duration of 32.3 months (SD ± 56.3), producing deep impairments in daily activities, sleep, and mood. We estimated a prevalence of 3.3% for FM (95% CI 2.5; 4.1) and 12% for NP (95% CI 10.6; 13.4). Female sex, fewer school years, and depressive symptoms were associated with FM and NP, whereas diabetes was only associated with NP. We standardized the results from our sample against the whole Chilean population and found no significant difference to our crude estimates. This is in line with studies from developed countries, highlighting the idea that despite genetic and environmental differences, the conditions that confer risk to CNCP remain stable.

摘要

尽管我们知道慢性疼痛(CP)影响了大约 30%的发达国家人口,但来自拉丁美洲的数据却很匮乏。此外,慢性非癌性疼痛(CNCP)、纤维肌痛(FM)和神经病理性疼痛(NP)等特定 CP 病症的患病率尚不清楚。为了在智利进行估计,我们前瞻性地招募了 1945 名参与者(61.4%为女性,38.6%为男性),年龄在 38 至 74 岁之间,来自一个农业城镇,他们回答了疼痛问卷、纤维肌痛调查问卷和 Douleur Neuropathique 4(DN4),以分别确定 CNCP、FM 和 NP。CNCP 的估计患病率为 34.7%(95%CI 32.6;36.8),平均持续时间为 32.3 个月(SD±56.3),对日常活动、睡眠和情绪造成了严重影响。我们估计 FM 的患病率为 3.3%(95%CI 2.5;4.1),NP 的患病率为 12%(95%CI 10.6;13.4)。女性、受教育年限较少和抑郁症状与 FM 和 NP 相关,而糖尿病仅与 NP 相关。我们将我们的样本结果与整个智利人口进行标准化,发现与我们的粗估计值没有显著差异。这与来自发达国家的研究一致,强调了尽管存在遗传和环境差异,但导致 CNCP 的风险条件仍然稳定的观点。

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