Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA.
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Hum Pathol. 2023 Mar;133:115-125. doi: 10.1016/j.humpath.2023.02.009. Epub 2023 Mar 7.
Neuroendocrine tumors of the prostate are rare and encompass a group of entities that are classified based on a combination of morphological and immunohistochemical features. Despite the 2016 World Health Organization classification of prostatic neuroendocrine tumors, variants have been reported that do not fit well in the categorization scheme. While the majority of these tumors arise in the setting of castration-resistant prostate cancer (postandrogen deprivation therapy), de novo cases may occur. In this review, we highlight the most significant pathological and immunohistochemical features, emerging biomarkers, and molecular features of such tumors.
前列腺神经内分泌肿瘤较为罕见，包含一组基于形态学和免疫组织化学特征相结合进行分类的实体瘤。尽管 2016 年世界卫生组织对前列腺神经内分泌肿瘤进行了分类，但仍有一些不符合分类方案的变异型被报道。这些肿瘤大多数发生在去势抵抗性前列腺癌（雄激素剥夺治疗后）背景下，但也可能为初发。在这篇综述中，我们重点介绍了这些肿瘤最重要的病理学和免疫组织化学特征、新兴的生物标志物以及分子特征。
