神经内分泌前列腺癌的影像学检查

Taher Ahmed, Jensen Corey T, Yedururi Sireesha, Surasi Devaki Shilpa, Faria Silvana C, Bathala Tharakeshwar K, Mujtaba Bilal, Bhosale Priya, Wagner-Bartak Nicolaus, Morani Ajaykumar C

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holocombe Blvd., Houston, TX 77030, USA.

Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Cancers (Basel). 2021 Nov 17;13(22):5765. doi: 10.3390/cancers13225765.

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that typically has a high metastatic potential and poor prognosis in comparison to the adenocarcinoma subtype. Although it can arise de novo, NEPC much more commonly occurs as a mechanism of treatment resistance during therapy for conventional prostatic adenocarcinoma, the latter is also termed as castration-resistant prostate cancer (CRPC). The incidence of NEPC increases after hormonal therapy and they represent a challenge, both in the radiological and pathological diagnosis, as well as in the clinical management. This article provides a comprehensive imaging review of prostatic neuroendocrine tumors.

神经内分泌前列腺癌（NEPC）是前列腺癌的一种侵袭性亚型，与腺癌亚型相比，通常具有较高的转移潜能和较差的预后。尽管NEPC可原发发生，但它更常见于传统前列腺腺癌治疗期间作为治疗抵抗的一种机制出现，后者也被称为去势抵抗性前列腺癌（CRPC）。激素治疗后NEPC的发病率会增加，它们在放射学和病理学诊断以及临床管理方面都构成挑战。本文对前列腺神经内分泌肿瘤进行了全面的影像学综述。