铑催化羧酸的直接脱羰基硼化反应。
Rh-Catalyzed Direct Decarbonylative Borylation of Carboxylic Acids.
机构信息
College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350002, P. R. China.
State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China.
出版信息
Chemistry. 2023 May 22;29(29):e202300184. doi: 10.1002/chem.202300184. Epub 2023 Apr 14.
Carboxylic acids are abundant, low cost and environmentally friendly, direct convert carboxylic acids into valued-added compounds are in high demand. Herein, we report a Rh(I) catalyzed direct decarbonylative borylation of aryl and alkyl carboxylic acid using TFFH as activator. This protocol features excellent functional-group tolerance and a broad substrate scope including natural product and drugs. A gram-scale decarbonylative borylation reaction of Probenecid is also presented. In addition, the utility of this strategy is highlighted by a one-pot decarbonylative borylation/ derivatization sequence.
羧酸丰富、成本低、环保，将羧酸直接转化为高附加值化合物的需求很高。在此，我们报告了一种使用 TFFH 作为活化剂的 Rh(I)催化的芳基和烷基羧酸的直接脱羰硼化反应。该方案具有出色的官能团耐受性和广泛的底物范围，包括天然产物和药物。还提出了丙磺舒的克脱羰硼化反应的克级规模实验。此外，通过一锅脱羰硼化/衍生化序列突出了该策略的实用性。
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