College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350002, P. R. China.
State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China.
Chemistry. 2023 May 22;29(29):e202300184. doi: 10.1002/chem.202300184. Epub 2023 Apr 14.
Carboxylic acids are abundant, low cost and environmentally friendly, direct convert carboxylic acids into valued-added compounds are in high demand. Herein, we report a Rh(I) catalyzed direct decarbonylative borylation of aryl and alkyl carboxylic acid using TFFH as activator. This protocol features excellent functional-group tolerance and a broad substrate scope including natural product and drugs. A gram-scale decarbonylative borylation reaction of Probenecid is also presented. In addition, the utility of this strategy is highlighted by a one-pot decarbonylative borylation/ derivatization sequence.
羧酸丰富、成本低、环保，将羧酸直接转化为高附加值化合物的需求很高。在此，我们报告了一种使用 TFFH 作为活化剂的 Rh(I)催化的芳基和烷基羧酸的直接脱羰硼化反应。该方案具有出色的官能团耐受性和广泛的底物范围，包括天然产物和药物。还提出了丙磺舒的克脱羰硼化反应的克级规模实验。此外，通过一锅脱羰硼化/衍生化序列突出了该策略的实用性。
