Aasted B, Bernstein D, Klapper D G, El Kholy A, Krause R M
Scand J Immunol. 1979;9(1):61-7. doi: 10.1111/j.1365-3083.1979.tb02707.x.
Human antibodies to streptococcal groups A and C carbohydrates were measured quantitatively with a radioimmunoassay using tyrosylated 125I carbohydrate. Analysis of acute and convalescent sera from people with groups A or C streptococcal pharyngeal infection or persistent carriage revealed a significant rise in antibodies. Inhibition reactions with the cold carbohydrate indicated the specificity of the elicited antibodies. In some instances, group C as well as group A antibodies occurred after group A pharyngeal infections. Further clinical and epidemiological studies are required to determine the significance of group-specific antibodies. Antistreptolysin-O (ASO) rises were observed in individuals with group C antibody responses after persistent group C pharyngeal carriage. For this reason, epidemiological surveys that rely primarily on ASO surveys to determine the incidence of group A streptococcal infections must be interpreted with caution, at least in the developing countries, where group C pharyngeal carriage is common.
采用酪氨酸化的¹²⁵I碳水化合物放射免疫分析法对人抗A组和C组链球菌碳水化合物抗体进行定量测定。对A组或C组链球菌咽峡炎感染或持续带菌者的急性期和恢复期血清分析显示，抗体显著升高。与冷碳水化合物的抑制反应表明所诱导抗体的特异性。在某些情况下，A组咽峡炎感染后会出现C组以及A组抗体。需要进一步的临床和流行病学研究来确定组特异性抗体的意义。在C组咽部持续带菌后出现C组抗体反应的个体中观察到抗链球菌溶血素O（ASO）升高。因此，至少在C组咽部带菌常见的发展中国家，主要依靠ASO检测来确定A组链球菌感染发病率的流行病学调查必须谨慎解读。
