Zettergren Anna, Jonson Mattias, Mellqvist Fässberg Madeleine, Najar Jenna, Rydberg Sterner Therese, Seidu Nazib M, Kern Silke, Blennow Kaj, Zetterberg Henrik, Skoog Ingmar, Waern Margda
Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Mölndal, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Affective Clinic, Gothenburg, Sweden.
Front Psychiatry. 2023 Feb 21;14:1101956. doi: 10.3389/fpsyt.2023.1101956. eCollection 2023.
There are few studies investigating genetic factors related to suicidal ideation or behavior in older adult populations. Our aim was to test associations between passive and active suicidal ideation and polygenic risk scores (PRSs) for suicidality and other traits of relevance for suicidality in old age (i.e. depression, neuroticism, loneliness, Alzheimer's disease, cognitive performance, educational attainment, and several specified vascular diseases) in a population-based sample aged 70 years and older.
Participants in the prospective H70 study in Gothenburg, Sweden, took part in a psychiatric examination that included the Paykel questions on active and passive suicidal ideation. Genotyping was performed with the Neurochip (Illumina). After quality control of the genetic data the sample included 3467 participants. PRSs for suicidality and other related traits were calculated based on summary statistics from recent GWASs of relevance. Exclusion of persons with dementia or incomplete data on suicidal ideation yielded 3019 participants, age range 70-101 years. Associations between past year suicidal ideation (any level) and selected PRSs were analysed using general estimation equation (GEE) models, adjusted for sex and age.
We observed associations between passive/active suicidal ideation and PRSs for depression (three versions), neuroticism, and general cognitive performance. After excluding individuals with current major depressive disorder (MDD), similar associations were seen with PRS for neuroticism, general cognitive performance and two PRSs for depression. No associations were found between suicidal ideation and PRSs for suicidality, loneliness, Alzheimer's disease, educational attainment, or vascular disease.
Our results could indicate which types of genetic susceptibility that are of importance for suicidality in old age, and these findings can help to shed light on potential mechanisms that may be involved in passive and active suicidal ideation in late-life, also in those with no current MDD. However, due to the limited sample size, the results need to be interpreted with caution until replicated in larger samples.
很少有研究调查老年人群中与自杀意念或行为相关的遗传因素。我们的目的是在一个基于人群的70岁及以上样本中，测试被动和主动自杀意念与自杀行为的多基因风险评分（PRSs）以及与老年自杀行为相关的其他特征（即抑郁、神经质、孤独感、阿尔茨海默病、认知能力、教育程度和几种特定的血管疾病）之间的关联。
瑞典哥德堡前瞻性H70研究的参与者参加了一项精神病学检查，其中包括关于主动和被动自杀意念的佩克尔问题。使用Neurochip（Illumina）进行基因分型。在对遗传数据进行质量控制后，样本包括3467名参与者。基于近期相关全基因组关联研究（GWASs）的汇总统计数据，计算出自杀行为和其他相关特征的PRSs。排除患有痴呆症或自杀意念数据不完整的人后，得到3019名参与者，年龄范围为70 - 101岁。使用一般估计方程（GEE）模型分析过去一年自杀意念（任何水平）与选定的PRSs之间的关联，并对性别和年龄进行了调整。
我们观察到被动/主动自杀意念与抑郁（三个版本）、神经质和一般认知能力的PRSs之间存在关联。排除当前患有重度抑郁症（MDD）的个体后，与神经质、一般认知能力的PRSs以及两个抑郁的PRSs之间也观察到了类似的关联。在自杀意念与自杀行为、孤独感、阿尔茨海默病、教育程度或血管疾病的PRSs之间未发现关联。
我们的结果可能表明哪些类型的遗传易感性对老年自杀行为很重要，这些发现有助于阐明可能与晚年被动和主动自杀意念有关的潜在机制，即使是那些目前没有MDD的人。然而，由于样本量有限，在更大样本中重复验证之前，这些结果需要谨慎解释。
