Engesser L, Kluft C, Briët E, Brommer E J
Gaubius Institute TNO, Leiden, The Netherlands.
Br J Haematol. 1987 Nov;67(3):355-8. doi: 10.1111/j.1365-2141.1987.tb02357.x.
A patient with spontaneous venous thrombotic events, myocardial infarction and a positive family history of thrombosis was investigated for underlying disorders of haemostasis. Abnormally high levels of histidine-rich glycoprotein were found. No other abnormality known or suspected of increasing the risk for thrombosis was present. Elevated levels of histidine-rich glycoprotein appeared to be present in four other members of the family over two generations suggesting a hereditary disorder. Further study on the relation of elevated histidine-rich glycoprotein levels and thrombosis is indicated.
一名患有自发性静脉血栓形成事件、心肌梗死且有血栓形成家族史阳性的患者接受了止血潜在疾病的检查。发现富含组氨酸糖蛋白水平异常升高。未发现其他已知或疑似增加血栓形成风险的异常情况。在两代人的另外四名家族成员中似乎也存在富含组氨酸糖蛋白水平升高的情况，提示这是一种遗传性疾病。有必要对富含组氨酸糖蛋白水平升高与血栓形成之间的关系进行进一步研究。
