Bull World Health Organ. 1997;75(3):177-89.
Inherited thrombophilias are common disorders with a worldwide distribution, including antithrombin, protein C, and protein S deficiencies as well as resistance to activated protein C. Increased understanding of these disorders suggests that thrombophilia can arise from interaction between defective genes and environmental factors. WHO and the international Society on Thrombosis and Haemostasis (ISTH) discussed the problems of inherited thrombophilia at a joint meeting held in Geneva on 6-8 November 1995. The present article reports on the various possibilities for controlling the disorder and makes a series of recommendations for diagnosis, treatment, and research into the condition.
遗传性血栓形成倾向是一种在全球范围内普遍存在的疾病，包括抗凝血酶、蛋白C和蛋白S缺乏症以及对活化蛋白C的抵抗。对这些疾病的进一步了解表明，血栓形成倾向可能源于缺陷基因与环境因素之间的相互作用。世界卫生组织（WHO）和国际血栓与止血学会（ISTH）于1995年11月6日至8日在日内瓦举行的一次联合会议上讨论了遗传性血栓形成倾向的问题。本文报告了控制该疾病的各种可能性，并就该疾病的诊断、治疗和研究提出了一系列建议。
