杀伤许可：维甲酸为 T 细胞的组织驻留编程。

License to kill: Retinoic acid programs T cells for tissue residency.

机构信息

Department of Molecular Biology, University of California, San Diego , La Jolla, CA, USA.

出版信息

J Exp Med. 2023 May 1;220(5). doi: 10.1084/jem.20230161. Epub 2023 Mar 10.

DOI:10.1084/jem.20230161

PMID:36897330

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10035436/

Abstract

In this issue of JEM, Qiu et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20210923) show that retinoic acid signaling during priming in the mesenteric lymph node licenses CD8+ T cells to develop into small intestinal tissue-resident memory cells, a finding that provides key insights into tissue-specific vaccination strategies.

摘要

在本期《实验医学杂志》中，Qiu 等人（2023. J. Exp. Med. https://doi.org/10.1084/jem.20210923）表明，在肠系膜淋巴结中的初始阶段，视黄酸信号会使 CD8+T 细胞获得许可，从而分化为小肠组织驻留记忆细胞，这一发现为组织特异性疫苗接种策略提供了重要的见解。