Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
J Glaucoma. 2023 Jun 1;32(6):458-465. doi: 10.1097/IJG.0000000000002197. Epub 2023 Mar 3.
The peripapillary vessel density decreased significantly in the affected hemiretina compared with that in the intact hemiretina in glaucomatous eyes with a single-hemifield retinal nerve fiber layer defect.
To evaluate the difference in the change rates of peripapillary vessel density (pVD) and macular vessel density (mVD) measured using optical coherence tomography angiography (OCTA) in glaucomatous eyes with a single-hemifield retinal nerve fiber layer (RNFL) defect.
We performed a retrospective, longitudinal study of 25 patients with glaucoma who were followed up for at least 3 years, with a minimum of 4 visits after baseline OCTA. At each visit, all participants underwent OCTA examination, and the pVD, mVD were measured by removing the large vessels. Changes in the pVD, mVD, peripapillary RNFL thickness (pRNFLT), and macular ganglion cell inner plexiform layer thickness were investigated in the affected and intact hemispheres, and the differences between the 2 hemispheres were compared.
In the affected hemiretina, the pVD, mVD, pRNFLT, and mCGIPLT were reduced than that in the intact hemiretina (all, P < 0.001). The changes in pVD and mVD were statistically significant at the 2-year and 3-year follow-ups in the affected hemifield (all, P <0.05). However, pVD and mVD did not show statistically significant changes in the intact hemiretina throughout the follow-up visits. Although the pRNFLT decreased significantly at the 3-year follow-up, the macular ganglion cell inner plexiform layer thickness showed no statistical change at any follow-up visit. Compared with the intact hemisphere, pVD was the only parameter that showed significant changes throughout the follow-up period.
Although pVD and mVD decreased in the affected hemiretina, the reduction in pVD was significant compared with that in the intact hemiretina.
与完整半侧视网膜相比，青光眼单一半视野神经纤维层缺损眼的视盘周围血管密度在受影响的半侧视网膜中显著降低。
评估光学相干断层扫描血管造影（OCTA）测量的青光眼单一半视野神经纤维层（RNFL）缺损眼的视盘周围血管密度（pVD）和黄斑血管密度（mVD）变化率的差异。
我们对 25 例至少随访 3 年、基线 OCTA 后至少随访 4 次的青光眼患者进行了回顾性、纵向研究。在每次就诊时，所有参与者均接受 OCTA 检查，并通过去除大血管来测量 pVD、mVD。研究了受影响和完整半球的 pVD、mVD、视盘周围 RNFL 厚度（pRNFLT）和黄斑神经节细胞内丛状层厚度的变化，并比较了 2 个半球之间的差异。
在受影响的半侧视网膜中，pVD、mVD、pRNFLT 和 mCGIPLT 均低于完整半侧视网膜（均 P <0.001）。在受影响的半视野中，pVD 和 mVD 在 2 年和 3 年的随访中均有统计学意义（均 P <0.05）。然而，在整个随访过程中，完整半侧视网膜的 pVD 和 mVD 均无统计学意义的变化。尽管在 3 年的随访中 pRNFLT 显著下降，但在任何随访中，黄斑神经节细胞内丛状层厚度均无统计学变化。与完整半球相比，pVD 是整个随访期间唯一显示出显著变化的参数。
尽管受影响的半侧视网膜的 pVD 和 mVD 均降低，但与完整半侧视网膜相比，pVD 的降低更为显著。
