Chung Jae Keun, Hwang Young Hoon, Wi Jae Min, Kim Mijin, Jung Jong Jin
a Department of Ophthalmology , Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute , Seoul , Republic of Korea.
Curr Eye Res. 2017 Nov;42(11):1458-1467. doi: 10.1080/02713683.2017.1337157. Epub 2017 Sep 14.
To investigate the glaucoma diagnostic abilities of vessel density parameters as determined by optical coherence tomography (OCT) angiography in different stages of glaucoma.
A total of 113 healthy eyes and 140 glaucomatous eyes were enrolled. Diagnostic abilities of the OCT vessel density parameters in the optic nerve head (ONH), peripapillary, and macular regions were evaluated by calculating the area under the receiver operation characteristic curves (AUCs). AUCs of the peripapillary vessel density parameters and circumpapillary retinal nerve fiber layer (RNFL) thickness were compared.
OCT angiography vessel densities in the ONH, peripapillary, and macular regions in the glaucomatous eyes were significantly lower than those in the healthy eyes (P < 0.05). Among the vessel density parameters, the average peripapillary vessel density showed higher AUC than the ONH and macular region (AUCs: 0.807, 0.566, and 0.651, respectively) for glaucoma detection. The peripapillary vessel density parameters showed similar AUCs with the corresponding sectoral RNFL thickness (P > 0.05). However, in the early stage of glaucoma, the AUCs of the inferotemporal and temporal peripapillary vessel densities were significantly lower than that of the RNFL thickness (P < 0.05).
The glaucomatous eyes showed decreased vessel density as determined by OCT angiography. Although the peripapillary vessel density parameters showed similar glaucoma diagnostic ability with circumpapillary RNFL thickness, in the early stage, the vessel density parameters showed limited clinical value.
研究光学相干断层扫描血管造影术（OCTA）测定的血管密度参数在青光眼不同阶段的青光眼诊断能力。
共纳入113只健康眼和140只青光眼患眼。通过计算受试者操作特征曲线下面积（AUC）评估OCT血管密度参数在视神经乳头（ONH）、视乳头周围和黄斑区的诊断能力。比较视乳头周围血管密度参数和视乳头周围视网膜神经纤维层（RNFL）厚度的AUC。
青光眼患眼的ONH、视乳头周围和黄斑区的OCT血管造影术血管密度显著低于健康眼（P<0.05）。在血管密度参数中，平均视乳头周围血管密度在检测青光眼时的AUC高于ONH和黄斑区（AUC分别为0.807、0.566和0.651）。视乳头周围血管密度参数与相应扇形RNFL厚度的AUC相似（P>0.05）。然而，在青光眼早期，颞下和颞侧视乳头周围血管密度的AUC显著低于RNFL厚度（P<0.05）。
OCT血管造影术显示青光眼患眼的血管密度降低。虽然视乳头周围血管密度参数与视乳头周围RNFL厚度具有相似的青光眼诊断能力，但在早期，血管密度参数的临床价值有限。
