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肾上腺素自动注射器损伤:三级手外科单位急诊管理中的实用考虑因素。

Adrenaline auto-injector injuries: Practical considerations in emergency management in a tertiary hand surgery unit.

机构信息

Royal Free Hospital Department of Plastic Surgery, London, United Kingdom.

University College London Medical School, London, United Kingdom.

出版信息

Medicine (Baltimore). 2023 Mar 10;102(10):e32977. doi: 10.1097/MD.0000000000032977.

Abstract

Adrenaline auto-injectors are the first line treatment for anaphylaxis in the community setting. Both anaphylaxis and auto-injector carriage are increasing in prevalence. Adrenaline auto-injector injuries are common and most often involve the hand or digits. Such injuries carry a risk of ischemic necrosis due to profound vasoconstriction, especially if there is undying vascular pathology such as Raynaud's disease. The effects can be readily reversed with local infiltration of phentolamine. A survey was circulated to 40 clinicians working in the emergency and hand surgery departments of a major urban center. Knowledge of adrenaline duration of action and its reversal (agent, dose and location in the hospital) was assessed. All clinicians working within the two departments were eligible for participation. Only 25% of clinicians surveyed were aware of the duration of action of adrenaline. Half were aware of the correct reversal agent and only 20% knew the correct dose. Only one person was aware of phentolamine's location within the hospital. There is relatively poor clinician knowledge surrounding adrenaline reversal and a lack of easily accessible information available about dosing and drug location within the hospital. Given the time dependent nature of adrenaline auto-injector injuries Emergency Departments should consider stocking phentolamine in an emergency drugs fridge within the department along with a dosing guide. This is likely to greatly reduce time from presentation to treatment and thus the chances of digital ischemia progressing to necrosis.

摘要

肾上腺素自动注射器是社区环境中治疗过敏反应的一线药物。过敏反应和自动注射器携带的情况都在增加。肾上腺素自动注射器损伤很常见,最常涉及手或手指。由于严重的血管收缩,这些损伤会导致缺血性坏死,尤其是存在雷诺病等未治愈的血管病理时。可以通过局部浸润苯肾上腺素来轻易逆转其影响。我们向一个大城市的急诊和手外科部门的 40 名临床医生分发了一份调查。评估了他们对肾上腺素作用持续时间及其逆转(药物、剂量和医院内位置)的了解。两个科室的所有临床医生都有资格参与。只有 25%的被调查临床医生了解肾上腺素的作用持续时间。一半的人了解正确的逆转药物,只有 20%的人知道正确的剂量。只有一个人知道苯肾上腺素在医院内的位置。关于肾上腺素的逆转,临床医生的知识相对较差,并且缺乏有关医院内药物剂量和位置的易于获取的信息。鉴于肾上腺素自动注射器损伤具有时间依赖性,急诊科应考虑在部门内的急救药品冰箱中储备苯肾上腺素,并附上剂量指南。这很可能大大缩短从就诊到治疗的时间,从而降低手指缺血进展为坏死的几率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70d2/9997809/1a7670712fe0/medi-102-e32977-g001.jpg

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