Affiliated Eye Hospital of Nanchang University, Nanchang, China.
Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, China.
Medicine (Baltimore). 2023 Mar 10;102(10):e33196. doi: 10.1097/MD.0000000000033196.
Given that there are controversial findings regarding vessel density in amblyopia, we quantified retinal microcirculation using optical coherence tomography angiography and compared it between hyperopic ametropic amblyopia eyes and age-matched control eyes. This case-control study was conducted from March 2021 to March 2022 at the Affiliated Eye Hospital of Nanchang University, Nanchang, China. Both groups included 72 eyes. Foveal avascular zone area, circularity and perimeter, perfusion density and vessel density of macular superficial retinal capillary plexus, macular thickness, macular volume, peripapillary retinal nerve fiber layer thickness, and ganglion cell-inner plexiform layer thickness were compared between hyperopia ametropic amblyopia eyes and age-matched control eyes. Additionally, best-corrected visual acuity, maximum corneal curvature, minimum corneal curvature, and anterior chamber depth were measured. In the hyperopia ametropic amblyopia eyes and control eyes, vessel density was 7.51 ± 2.13 and 9.91 ± 2.71 mm-1 in the central, 17.20 ± 1.38 and 18.25 ± 1.37 mm-1 in the inner, and 17.90 ± 0.88 and 18.43 ± 0.97 mm-1 in the full regions, respectively. The perfusion densities were 0.17 ± 0.06 and 0.23 ± 0.07 in the central, 0.41 ± 0.05 and 0.44 ± 0.03 in the inner, and 0.44 ± 0.03 and 0.46 ± 0.02 in the full regions, respectively. The central macular thicknesses of hyperopia ametropic amblyopia and control eyes were 240.04 ± 20.11 and 235.08 ± 24.41 µm, respectively. Foveal avascular zone perimeter and circularity (P < .043 and P = .001) significantly differed between the 2 groups. Hyperopia ametropic amblyopia eyes showed lower appreciably in vessel and perfusion densities, which could be one of the major pathophysiological mechanisms of hyperopia ametropic amblyopia and provide a new direction for the diagnosis and treatment of amblyopia.
鉴于在弱视中存在血管密度的争议性发现，我们使用光相干断层扫描血管造影术来量化视网膜微循环，并将其与远视性屈光不正性弱视眼和年龄匹配的对照组进行比较。这项病例对照研究于 2021 年 3 月至 2022 年 3 月在中国南昌大学附属眼科医院进行。两组均包括 72 只眼。比较远视性屈光不正性弱视眼和年龄匹配的对照组之间的黄斑无血管区面积、圆度和周长、黄斑浅层视网膜毛细血管丛的灌注密度和血管密度、黄斑厚度、黄斑体积、视盘周围视网膜神经纤维层厚度和节细胞内丛状层厚度。此外，还测量了最佳矫正视力、最大角膜曲率、最小角膜曲率和前房深度。在远视性屈光不正性弱视眼和对照组中，中央区血管密度分别为 7.51±2.13mm-1 和 9.91±2.71mm-1，内区分别为 17.20±1.38mm-1 和 18.25±1.37mm-1，全区分别为 17.90±0.88mm-1 和 18.43±0.97mm-1。中央区的灌注密度分别为 0.17±0.06 和 0.23±0.07，内区分别为 0.41±0.05 和 0.44±0.03，全区分别为 0.44±0.03 和 0.46±0.02。远视性屈光不正性弱视眼和对照组的中央黄斑厚度分别为 240.04±20.11μm 和 235.08±24.41μm。两组之间黄斑无血管区周长和圆度（P<0.043 和 P=0.001）差异显著。远视性屈光不正性弱视眼的血管和灌注密度明显降低，这可能是远视性屈光不正性弱视的主要病理生理机制之一，为弱视的诊断和治疗提供了新的方向。
