Department of Pediatric Ophthalmology, Peking University First Hospital Peking University Peadatriac Visions Research Center, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.
BMC Ophthalmol. 2022 Jun 20;22(1):269. doi: 10.1186/s12886-022-02486-9.
To observe and compare the difference in retinal perfusion using optical coherence tomography angiography (OCTA) between anisometropic amblyopia in children and fellow eyes as well as age-matched controls.
A total of 16 children with anisometropic amblyopia and 19 age-matched healthy subjects were enrolled. All participants underwent OCTA examination, with 3 mm × 3 mm and 6 mm × 6 mm scans in the macular region. Perfusion parameters of the superficial retinal layer were measured by built-in software, including the macular foveal avascular zone (FAZ) area, perimeter and circularity, as well as the vessel length density (VLD) and perfusion density (PD) of the foveal, parafoveal and perifoveal regions.
Among the 16 patients with anisometropic amblyopia, the FAZ area was significantly higher in diseased eyes (P = 0.027) than in fellow eyes. The VLD and PD of the foveal average and the VLD of the nasal quadrant of the perifoveal region in anisometropic amblyopic eyes were significantly lower than those in fellow eyes (P < 0.05). The VLD of the parafoveal average, the superior, temporal, inferior and nasal quadrants of the parafoveal region, and the nasal quadrant of the perifoveal region in anisometropic amblyopic eyes were significantly lower than those in healthy controls (P < 0.05). The PD of the parafoveal average, and the inferior quadrant of the parafoveal region in anisometropic amblyopic eyes were significantly lower than those in healthy controls (P < 0.05). The VLD of the parafoveal average, the superior, inferior and nasal quadrants of the parafoveal region, and the nasal quadrant of the perifoveal region in fellow eyes were significantly lower than those in healthy controls (P < 0.05). The PD of the parafoveal average, and the inferior quadrant of the parafoveal region in fellow eyes were significantly lower than those in healthy controls (P < 0.05).
The macular vessel density of the superficial capillary plexus is lower in anisometropic amblyopic children than in age-matched healthy children. Compared with the fellow eye, the perfusion of the amblyopic eye in children with anisometropic amblyopia also decreases.
利用光相干断层扫描血管造影术（OCTA）观察并比较儿童屈光参差性弱视眼与对侧眼及年龄匹配对照组之间视网膜血流灌注的差异。
共纳入 16 例屈光参差性弱视儿童和 19 例年龄匹配的健康受试者。所有受试者均接受 OCTA 检查，黄斑区扫描面积为 3mm×3mm 和 6mm×6mm。采用内置软件测量视网膜浅层血流灌注参数，包括黄斑中心凹无血管区（FAZ）面积、周长和面积比，以及黄斑区、旁中心凹区和中心凹周围区的血管长度密度（VLD）和血流密度（PD）。
在 16 例屈光参差性弱视患者中，病眼 FAZ 面积明显高于对侧眼（P=0.027）。弱视眼的黄斑区平均 VLD 和 PD 以及中心凹周围区鼻象限 VLD 明显低于对侧眼（P<0.05）。弱视眼的旁中心凹区平均 VLD、上象限、颞象限、下象限和鼻象限以及中心凹周围区鼻象限 VLD 明显低于健康对照组（P<0.05）。弱视眼的旁中心凹区平均 PD 以及下象限 PD 明显低于健康对照组（P<0.05）。弱视眼的旁中心凹区平均 VLD、上象限、下象限和鼻象限以及中心凹周围区鼻象限 VLD 明显低于对侧眼（P<0.05）。弱视眼的旁中心凹区平均 PD 以及下象限 PD 明显低于健康对照组（P<0.05）。
屈光参差性弱视儿童的浅层毛细血管丛黄斑区血管密度低于年龄匹配的健康儿童。与对侧眼相比，儿童屈光参差性弱视眼的血流灌注也减少。
