东亚地区幽门螺杆菌感染患者的结直肠癌风险：系统评价和荟萃分析。

Colorectal cancer risk in East Asian patients with Helicobacter pylori infection: A systematic review and meta-analysis.

机构信息

Shenzhen Traditional Chinese Medicine Anorectal Hospital Futian, Shenzhen, China.

出版信息

Medicine (Baltimore). 2023 Mar 10;102(10):e33177. doi: 10.1097/MD.0000000000033177.

DOI:10.1097/MD.0000000000033177

PMID:36897722

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9997759/

Abstract

BACKGROUND

The aim of this systematic review and meta-analysis was to assess the relationship between H pylori infection and colorectal cancer risk in East Asian patients.

METHODS

Two researchers independently searched for relevant studies in the PubMed, Cochrane, and Embase databases from inception up to April 2022. A meta-analysis was then performed to calculate pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) using a random effects model.

RESULTS

Nine studies involving 6355 patients were included. Overall, we observed that H pylori infection was associated with an increased risk of colorectal cancer in East Asian patients (OR = 1.48, 95% CI: 1.10-1.99, I2 = 70%), although significant heterogeneity was identified among studies. Subgroup analysis revealed that H pylori infection was associated with an increased risk of colorectal cancer in China (OR = 1.58, 95% CI 1.05-2.37, I2 = 81%) but not in Japan and Korea (OR = 1.26, 95% CI 0.93-1.70, I2 = 0%).

CONCLUSION

This meta-analysis identified a positive association between H pylori infection and colorectal cancer risk in East Asian patients, especially in China.

摘要

背景

本系统评价和荟萃分析的目的是评估东亚人群中 H pylori 感染与结直肠癌风险之间的关系。

方法

两名研究人员独立检索了 PubMed、Cochrane 和 Embase 数据库中从建库至 2022 年 4 月的相关研究。然后采用随机效应模型计算汇总优势比（OR）及其相应的 95%置信区间（CI）。

结果

纳入了 9 项涉及 6355 名患者的研究。总体而言，我们发现 H pylori 感染与东亚人群结直肠癌风险增加相关（OR=1.48，95%CI：1.10-1.99，I2=70%），尽管研究之间存在显著异质性。亚组分析显示，H pylori 感染与中国人群结直肠癌风险增加相关（OR=1.58，95%CI 1.05-2.37，I2=81%），但与日本和韩国人群无关（OR=1.26，95%CI 0.93-1.70，I2=0%）。