肥厚型大鼠肾脏中的脂质过氧化作用。

Lipid peroxidation in hypertrophic rat kidney.

作者信息

Laskowska-Klita T, Szumiło M

机构信息

Department of Biochemistry, Medical School, Warsaw, Poland.

出版信息

Biochim Biophys Acta. 1987 Dec 14;922(3):386-9. doi: 10.1016/0005-2760(87)90063-4.

DOI:10.1016/0005-2760(87)90063-4

PMID:3689817

Abstract

During compensatory growth of kidney, microsomal lipid peroxidation is unchanged in the hypertrophy phase and is doubled in a period of hyperplasia. The maximum lipid peroxidation is preceded by a 2-fold increase in the content of cytochrome P-450. Both in microsomes and cytosol, intense peroxidation of lipids is accompanied by a decrease in glutathione content.

摘要

在肾脏代偿性生长过程中，微粒体脂质过氧化在肥大阶段保持不变，而在增生期增加一倍。脂质过氧化最大值出现之前，细胞色素P - 450含量增加两倍。在微粒体和胞质溶胶中，脂质的强烈过氧化都伴随着谷胱甘肽含量的降低。