大鼠肝脏中针对微粒体脂质过氧化的胞质防御系统的发育

Development of the cytosolic defence system against microsomal lipid peroxidation in rat liver.

作者信息

Fairhurst S, Barber D J, Clark B, Horton A A

出版信息

Biochim Biophys Acta. 1983 Aug 1;752(3):491-6. doi: 10.1016/0005-2760(83)90281-3.

DOI:10.1016/0005-2760(83)90281-3

Abstract

Ascorbate-induced lipid peroxidation in rat liver microsomes reaches the adult level in 2-3 days. NADPH-induced peroxidation develops more gradually, in parallel with the activity of NADPH-cytochrome P-450 reductase, attaining adult levels by 10-12 days. The glutathione-dependent cytosolic enzyme activity which inhibits peroxidation is inhibited by bromosulphophthalein. The development of this system lags behind the development of microsomal lipid peroxidation between the ages of 2 and 20 days, allowing peroxidation to proceed.

摘要

抗坏血酸盐诱导的大鼠肝脏微粒体脂质过氧化在2 - 3天内达到成年水平。NADPH诱导的过氧化发展较为缓慢，与NADPH - 细胞色素P - 450还原酶的活性平行，在10 - 12天达到成年水平。抑制过氧化的谷胱甘肽依赖性胞质酶活性受到溴磺酞的抑制。该系统的发育在2至20天龄之间落后于微粒体脂质过氧化的发育，从而使过氧化得以进行。

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