Dawid de Vera Maria Teresa, Prieto Cuadra Juan Daniel, Domínguez Pinos Dolores, Hierro Martín Isabel
Unidad de Gestión Clínica (UGC) de Anatomía Patológica, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga, Spain.
Unidad de Gestión Clínica (UGC) de Anatomía Patológica, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Málaga, Spain
BMJ Case Rep. 2023 Mar 10;16(3):e250061. doi: 10.1136/bcr-2022-250061.
A long-term female smoker presented to the emergency department with cough, greenish mucus and dyspnoea, without fever. The patient also reported abdominal pain and significant weight loss in recent months. Laboratory tests showed leucocytosis with neutrophilia, lactic acidosis and a faint left lower lobe consolidation on chest X-ray, for which she was admitted to the pneumology department and started on broad-spectrum antibiotherapy. After 3 days of clinical stability, the patient deteriorated rapidly, with worsening of analytical parameters and coma. The patient died a few hours later. Given the rapid and unexplained evolution of the disease, a clinical autopsy was requested, which revealed a left pleural empyema caused by perforated diverticula by neoplastic infiltration of biliary origin.
一名长期吸烟的女性因咳嗽、绿色黏液和呼吸困难前往急诊科就诊,无发热症状。患者还自述近几个月来腹痛且体重显著减轻。实验室检查显示白细胞增多伴中性粒细胞增多、乳酸酸中毒,胸部X线显示左下叶有模糊的实变影,为此她被收入呼吸内科并开始接受广谱抗生素治疗。在临床稳定3天后,患者病情迅速恶化,分析指标恶化并陷入昏迷。患者数小时后死亡。鉴于病情迅速且原因不明地进展,遂要求进行临床尸检,结果显示为源于胆管的肿瘤浸润导致憩室穿孔引起的左侧胸膜积脓。