Institute of Medical Biology (IMB) / Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), 11 Mandalay Road, Clinical Sciences Building #17-01, Singapore, 308232, Republic of Singapore.
NUS Graduate School, National University of Singapore, Singapore, 119077, Republic of Singapore.
Sci Rep. 2023 Mar 10;13(1):4027. doi: 10.1038/s41598-023-30411-7.
Niche cells are widely known to regulate stem/progenitor cells in many mammalian tissues. In the hair, dermal papilla niche cells are well accepted to regulate hair stem/progenitor cells. However, how niche cells themselves are maintained is largely unknown. We present evidence implicating hair matrix progenitors and the lipid modifying enzyme, Stearoyl CoA Desaturase 1, in the regulation of the dermal papilla niche during the anagen-catagen transition of the mouse hair cycle. Our data suggest that this takes place via autocrine Wnt signalling and paracrine Hedgehog signalling. To our knowledge, this is the first report demonstrating a potential role for matrix progenitor cells in maintaining the dermal papilla niche.
龛细胞被广泛认为能调节许多哺乳动物组织中的干细胞/祖细胞。在毛发中，真皮乳头龛细胞被认为可以调节毛囊干细胞/祖细胞。然而，龛细胞本身是如何维持的，在很大程度上还不清楚。我们提出的证据表明，在小鼠毛囊周期的生长期-退行期转换过程中，毛发基质祖细胞和脂质修饰酶硬脂酰辅酶 A 去饱和酶 1 （Stearoyl CoA Desaturase 1）参与调节真皮乳头龛细胞。我们的数据表明，这是通过自分泌 Wnt 信号和旁分泌 Hedgehog 信号发生的。据我们所知，这是首次报道基质祖细胞在维持真皮乳头龛细胞中可能发挥作用。
